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GHS Classification Result

Chemical Name：nitrilotriacetic acid
CAS：139-13-9

Result：


ID:	170
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	-	-	-	-	Solid (GHS definition)
7	Flammable solids	Not classified	-	-	-	-	Non-combustible (ICSC (J), 1994; Weiss, 2nd, 1986, p735)
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9	Pyrophoric liquids	Not applicable	-	-	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	-	-	-	-	Non-combustible (ICSC (J), 1994; Weiss, 2nd, 1986, p735)
11	Self-heating substances and mixtures	Not classified	-	-	-	-	Non-combustible (ICSC(J) (1994), Weiss (2nd 1986) p735)
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	-	-	-	-	Solid (GHS definition)
14	Oxidizing solids	Not applicable	-	-	-	-	Organic compounds containing oxygen (but not chlorine and fluorine) and the oxygen is chemically bonded only to carbon and hydrogen (but not to other elements).
15	Organic peroxides	Not applicable	-	-	-	-	Containing no -0-0- structure
16	Corrosive to metals	Classification not possible	-	-	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	Since rat LD50s were 1100mg/kg(RTECS, 2005), 1100 to 1470 mg/kg (CERI Hazard Data (2002)), 1470mg/kg(BUA(1986)), and SITTIG (4th, 2002) ,and any LD50 was within the scope of Category 4, it was set as Category 4.
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available
2	Skin corrosion/irritation	Category 2		Warning	H315: Causes skin irritation	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse.	There are descriptions that it irritates human skin (HSFS (2001), SITTIG (2002)), and "As this article is a strong acids, it is supposed to have irritation. There is no laboratory reports." (CERI Hazard Data (2002)), So it was classified as Category 2.
3	Serious eye damage/eye irritation	Category 2A-2B		Warning	H319: Causes serious eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection.	Since there is description that eye irritation is admitted in humans in HSDB (2005), and there is description of "Since this substance is a strong acid, it is guessed that it has irritation. There is no laboratory reports. "in CERI Hazard Data(2002), it was referred to as Category 2A-2B.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Classification not possible	-	-	-	-	No data available
5	Germ cell mutagenicity	Category 1B		Danger	H340: May cause genetic defects	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Although the dominant lethal tests using mice cited in IARC 73 (1999) and CERI Hazard Data (2002) are negative, it is recorded that the in vivo chromosome aberration test using mouse spermatogenic cells was positive. So the substance was classified as Category 1B.
6	Carcinogenicity	Category 2		Warning	H351: Suspected of causing cancer	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	It is classified into group 2B in IARC (IARC 73 (1999)) and Japan Society for Occupational Health (Japan Society for Occupational Health recommendation (2005)) and is classified into group R according to NTP (NTP RoC (11th, 2005)). So it was set as Category 2.
7	Reproductive toxicity	Not classified	-	-	-	-	In the teratogenicity studies of the rat administration in drinking water, there are descriptions that although hydronephrosis and bladder disorders were observed in the embryo, there was no influence in growth of embryo, fetuses, and offspring. (IARC 73 (1999) and CERI Hazard Data Description (2002)). Moreover, in the teratogenicity test of administration in drinking water to a mouse, feeding administration to a rat, and oral administration to a rabbit, there are descriptions that there is no fetal malformations, and no influcences on growth of the reproductive function and potential, and offspring development in the two-generation reproduction study in a rat. These were judged as minimum influence to the reproductive function and potential, and fetus. Therefore, it was out of the Category.
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	Insufficient data available.
9	Specific target organ toxicity - Repeated exposure	Category 2 (kidney)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (kidney)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	There is no case report in human and in IARC 48 (1990) and CERI Hazard Data (2002) in orally and mixed feed administration for 28 - 90 days to rat or mouse, vacuolation of proximal convoluted tubule epithelial cells, the increase and erosion of interstitial transitional epithelium, and hydronephrosis were reported, and in IARC 48 (1990) it has the nephrotoxicity, due to these descriptions it is considered that target organ was the kidney, and it was classified into Category 2.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 3	-	-	H402: Harmful to aquatic life	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	It was classified into Category 3 from 72-hour ErC50=46000microg/L of algae (Green algae) (MOE Risk Assessment No.3, 2004).
11	Hazardous to the aquatic environment （Long-term）	Category 3	-	-	H412: Harmful to aquatic life with long lasting effects	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	Classified into Category 3, since acute toxicity was Category 3 and not rapidly degrading (BOD: 1% (existing chemical safety inspections data)), though less bio-accumulative (BCF=131 (existing chemical safety inspections data)).

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model SDS by MHLW	MHLW Website （in Japanese Only）