Chemical Name:2,4-Toluenediamine
CAS:95-80-7
ID: | 167 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | Containing no chemical groups with explosive properties |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
6 | Flammable liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
7 | Flammable solids | Not classified | - | - | - | - | Classified as "flammable" according to ICSC (2004). Classified into Division 6.1 (UN#1709 (solid)) (UN Recommendations on the Transport of Dangerous Goods) |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Containing no chemical groups with explosive or self-reactive properties |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
10 | Pyrophoric solids | Classification not possible | - | - | - | - | No data available |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available (melting point: 99degC (ICSC, 2004), test temperature: 140degC) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
14 | Oxidizing solids | Not applicable | - | - | - | - | Organic compounds containing no oxygen, fluorine and chlorine |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 | Danger | H301: Toxic if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the LD50 value of 135mg/kg calculated from the testing data of rat LD50 (oral route) of 73mg/kg, 300mg/kg (CERI Hazard Data 2000-8 (2001)), 230mg/kg and 270mg/kg (DFGOT vol.6 (1994)). | |
1 | Acute toxicity (Dermal) | Category 3 | Danger | H311: Toxic in contact with skin |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment (see ... on this label). P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the LD50 value of 650mg/kg representing the lower of the two testing data of rat LD50 of 1,200mg/kg (CERI Hazard Data 2000-8 (2001)) and rabbit LD50 of 650mg/kg (MOE Risk Assessment vol.3 (2004)). | |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected. |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | Insufficient data available |
2 | Skin corrosion/irritation | Category 3 | - | Warning | H316: Causes mild skin irritation | P332+P313: If skin irritation occurs: Get medical advice/attention. | Based on the description in the report on rabbit skin irritation tests (24-hour application) (CERI Hazard Data 2000-8 (2001)): "slightly irritating" (though the results are not those of 4-hour application). |
3 | Serious eye damage/eye irritation | Category 2A | Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
Based on the description in the report on rabbit eye irritation tests (CERI Hazard Data 2000-8 (2001), DFGOT vol.6 (1994)): "moderate irritation," and "mild conjunctivitis." The substance is thus considered a moderate irritant. | |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
4 | Skin sensitization | Category 1 | Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment (see ... on this label). P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
Based on the description in the report on guinea pig skin sensitization tests (CERI Hazard Data 2000-8 (2001) and DFGOT vol.6 (1994)): "slight sensitization," "sensitization effects observed." The substance is thus considered a sensitizing skin irritant. | |
5 | Germ cell mutagenicity | Not classified | - | - | - | - | Based on negative data on multi-generation mutagenicity tests (dominant lethal tests) and somatic cell mutagenicity tests in vivo (spot tests, micronucleus tests and chromosome aberration tests), and the absence of germ cell mutagenicity tests in vivo, described in EHC 74 (1987), NTP DB (Access on Feb., 2006), CERI-NITE Hazard Data 2000-8 (2001) and DFGOT vol.6 (1994). |
6 | Carcinogenicity | Category 2 | Warning | H351: Suspected of causing cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Due to the fact that the substance is classified as Category R by NTP (2005) and Group 2B by IARC (1987). | |
7 | Reproductive toxicity | Category 2 | Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the evidence of adverse effects on male fertility and development in pups (though no data are available on parental toxicity), described in EHC 74 (1987), MOE Risk Assessment vol.3 (2004), CERI-NITE Hazard Data 2000-8 (2001), DFGOT vol.6 (1994). | |
8 | Specific target organ toxicity - Single exposure | Category 1 (liver, central nervous system, blood system), Category 3 (respiratory tract irritation) |
Danger Warning |
H370: Causes damage to organs (liver, central nervous system, blood system) H335: May cause respiratory irritation (respiratory tract irritation) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
Based on the human evidence including: "The substance possesses hepatic toxicity, causing fatty liver. The effects on respiratory organs include coughing and dyspnea" (CERI Hazard Data 2000-8 (2001)), "Oral ingestion causes abdominal pain; leads to headache, dizziness, nausea, delirium, spasm and loss of consciousness" (MOE Risk Assessment vol.3 (2004)), and the evidence from animal studies including "methemoglobin formation" (EHC 74 (1987)), "methemoglobin formation, decreased osmotic resistance of red blood cell, increased Heinz bodies" (CERI Hazard Data 2000-8 (2001)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. | |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (liver, kidney), Category 2 (blood system, spleen, testis) |
Danger Warning |
H372: Cause damage to organs through prolonged or repeated exposure (liver, kidney) H373: May cause damage to organs through prolonged or repeated exposure (blood system, spleen, testis) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the evidence from animal studies including "centrolobular necrosis" (NTP TR162 (1979)), "increased hematopoiesis and vacuolation of hepatocytes" (MOE Risk Assessment vol.4 (2005)), "chronic renal disease, fatty degeneration and diffuse changes of hepatocytes" (CERI Hazard Data 2000-8 (2001)), "atrophy of the spleen/testes" (BUA 192 (1998)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Categories 1and 2. | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 2 | - | - | H401: Toxic to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It was classified into Category 2 from 48 hours EC50=1.6mg/L of the crustacea (Daphnia magna) (CERI/NITE Hazard Assessment Report (preliminary version), 2006). |
11 | Hazardous to the aquatic environment (Long-term) | Category 2 | - | H411: Toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Although acute toxicity was Category 2 and the bio-accumulation potential was low (BCF<50(Existing Chemical Safety Inspections Data)), since there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 2. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website (in Japanese Only) |