GHS Classification Result

Chemical Name:Triglycidyl isocyanurate
CAS:2451-62-9

Result:
ID: 163
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available by regulated examination methods, though there is a data on its flash point.
8 Self-reactive substances and mixtures Classification not possible - - - - No data available
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Flash point: 200degC (ICSC (J), 1997)
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) and the oxygen is chemically bonded only to carbon and hydrogen (but not to other elements).
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on rat oral LD50 = 950 mg/kg, 255 mg/kg (upper and lower limits given in CERI Hazard Data (2002)), and 715 mg/kg and 188 mg/kg (upper and lower limits of CICAD 8 (1998)), it was set as Category 3 from LD50= 226mg/kg obtained by adapting the calculation formula.
1 Acute toxicity (Dermal) Not classified - - - - Since data of rat percutaneous LD50 >3100mg/kg (CERI Hazard Data (2002)), >2000mg/kg (CICAD 8 (1998) and that toxic symptoms which suggest Category 5 were not reported, it was set as the outside of Category.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
It was set as Category 3 based on rat inhalation (dust) LC50 = 650mg/m3 (CICAD 8 (1998)).
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
Based on the descriptions that TGIC operating workers show human skin irritation (NICNAS (1994)), and that mild moderate skin irritation on rabbits (CERI Hazard Data (2002), CICADS 8 (1998), ACGIH (7th, 2001), and NICNAS (1994)), it was classified as Category 2.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
There are descriptions that the TGIC operation workers have eye irritation in humans (NICNAS (1994)), and that severe irritation was indicated in rabbit eye (CERI Hazard Data (2002), NICNAS (1994), and ACGIH (7th, 2001)). But irreversible impacts were not reported in both humans and rabbits. So it was set to Category 2A.
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ...
Classified as Category 1 because CERI Hazard Data (2001) describes that a worker who was using as a spray the paint containing 4% of this product developed asthma four years after starting the work, concluding that this product is the cause.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Classified as Category 1 because CERI Hazard Data (2001), ACGIH (7th, 2001) and NICNAS (1994) describe the patch test of the patient who developed contact dermatitis by occupational exposure shows positive for this product, which is judged to induce any symptoms, and CERI Hazard Data (2001) describes that several experiments using guinea pigs show sensitization, and CICAD 8 (1998) confirmed 25% and 60% positive rates in the two modified Magnusson and Kligman methods using guinea pigs.
5 Germ cell mutagenicity Category 1B Danger H340: May cause genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Although the dominant lethal tests in mice cited in CICAD 8(1998), ACGIH (7th, 2001) and CERI Hazard Data (2001) are negative for both oral administration and inhalation exposure, there are several positive results from the in vivo chromosome aberration tests using mouse spermatogonia in CICAD 8 (1998) and CERI Hazard Data (2001). So substance was classified as Category 1B.
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Classification not possible - - - - There is the description that there is no effect to fertility property and to embryo/offspring in the mating with normal male, though there is the mild low sperm count related with dose in the 13-week oral administration test to male mouse (feeding 100ppm as maximum). But the resultant information is limited. Since data is insufficient, it cannot classify.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Insufficient data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Since there is no evidence which it induces toxic symptoms with the repeated exposure to human and no data the repeated exposure experimentation in the animals for 14 days or more, it cannot be classified.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - It carried out the outside of Category from 96-hour LC50>77mg/L of fishes (Zebrafish) (NICNAS, 2001).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since not water-insoluble (water solubility=1190mg/L(PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


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