GHS Classification Result

Chemical Name：Ethane, 1,1,1-trichloro-
CAS：71-55-6

Result：
ID: 159
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Flash point: none (Hommel, 1991; Card No.196; Sax, 8th, 1992, p 2287 to 2288)
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Nonflammable. (Merck (Access on May 2005))
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - Non-flammable (Merck, access on May 2005)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing chlorine (but not oxygen and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 6.1

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on rat oral LD50 value = 4640mg/kg (CERI Hazard Data (1998)), 15800mg/kg (CERI Hazard Data (1998)), 11000mg/kg (EHC 136 (1992)), 10300mg/kg (PATTY (4th, 1994), ATSDR (2004)), and 12996mg/kg (ATSDR (2004)), calculation value was applied to make Category. LD50 calculated value = 7924.3 mg/kg
1 Acute toxicity （Dermal） Not classified - - - - It was categorized to use calculated LD50 value = 10706mg/kg. This value based on rabbit percutaneous LD50 value = 10000mg/kg (CERI Hazard Data (1998)), 16000mg/kg (CERI Hazard Data (1998)), and 15800mg/kg (EHC 136 (1992)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Not classified - - - - Rat inhalation LC50 (1 hour) value = 24000ppm (from steam pressure, it was judged to be steam. 4 hour exposure equivalent value is 12000ppm. CERI Hazard Data (1998)), and based on rat inhalation LC50 (4 hours) value = 18400ppm (EHC 136 (1992)), since this LC50 value indicate that the state of this compound was steam close to gas phase, Category was determined using the same standard values as for gases. LC50 value with 4-hour exposure is about 1.5 times the value of the limit of Category 5 (5000 - 12500ppm). Since the 4-hour equivalent obtained from LC50 value with 1 hour exposure was almost the same as the upper limit of Category 5, it was classified as out of Category.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		From descriptions that it shows irritation in human exposure cases (EHC 136 (1992), ATSDR (2004)), that moderate irritation was found on rabbits (CERI Hazard Data (1998), EHC 136 (1992), and ATSDR (2004)), and that moderate irritation was found on guinea pigs (CERI Hazard Data (1998), ACGIH (7th, 2001), and ATSDR (2004)), it was classified as Category 2.
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		From description that mild irritation was seen in humans evidence of exposure (EHC 136 (1992), ATSDR (2004)), and from description that the mild or moderate irritation was acknowledged with the rabbit (CERI Hazard Data(1998), EHC 136 (1992), PATTY (4th, 1994) and ATSDR (2004)), it was set as Category 2A-2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - One case of allergic contact dermatitis is reported without mentioning the possibility that the added stabilizer is its cause (ATSDR (2004)). In addition, one case is reported that a detergent including this product induced allergic reactions without specifying the causative agent (BUA 156 (1994)). On the other hand, because of a description that 50 volunteers with 18 cutaneous administration for three weeks showed no allergic skin reactions (BUA 156 (1994)), and a description that a guinea pig test showed no skin sensitization (BUA 156 (1994)), we classified this as out of category judging that there is no skin sensitization.
5 Germ cell mutagenicity Not classified - - - - The substance was regarded as outside the categories. Because the dominant lethal tests in mice are negative (CERI Hazard Data (1998), EHC 136 (1992)), and the in vivo mutagenicity tests using somatic cells (the chromosome aberration tests in rat bone-marrow cells, and micronucleus test in mouse bone-marrow/peripheral blood cells) are negative (CERI Hazard Data (1998), EHC 136 (1992), IARC 71 (1999), NTP DB (Access on Aug 2005), ATSDR (2004)).
6 Carcinogenicity Not classified - - - - It is classified into D according to EPA, and classified into a group 3 according to D and IARC 71 (1999) and is classified into A4 according to ACGIH (7th, 2001). So it was considered as the outside of Category.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Minimal effects are observed, such as mutation, delayed ossification, and low body weight in fatus/born child, in spite of observing bat effects on reproductive function, fertility property and generations in using rats, mice, and rabbits before mating, during pregnancy or lactating administration test (CERI Hazard Data Description (1998), EHC 136 (1992), PATTY (4th, 1994), IARC 71 (1999), NTP DB (Access on Aug 2005), ATSDR (2004), and ACGIH (7th, 2001)). On the other hand, there is a report that increase in mortality rate and change in behavior of offspring are observed at the dose affecting parental animals of general toxicity in a pregnant rat inhalation exposure test (CERI Hazard Data Description (1998) and ATSDR (2004)). Therefore, it was classified into Category 2. In addition, although there is a description of an epidemiological study, the clear association between reproductive toxicity and exposure is not indicated (ATSDR (2004)).
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system, heart), Category 3 (narcotic effects, respiratory tract irritation) Danger
Warning 		H370: Causes damage to organs (central nervous system, heart)
H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation)
H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		There is the descriptions that CNS depression effect is observed in the human exposure example in CERI Hazard Data (1998), EHC 136 (1992), ACGIH (7th, 2001), PATTY (4th, 1994), IARC 71 (1999), industrial hygene academic society advice, and ATSDR (2004). And that in the human exposure example the abnormal heart rhythm by cardic hypersensitivity to adrenalin effect in CERI Hazard Data, PATTY (4th, 1994), and ATSDR (2004). So it is considered that the target organs are central nervous systems and heart. Therefore, it was classified into Category 1. Moreover, due to the descriptions that the anesthetic action was observed in human exposure example in CERI Hazard Data (1998), ATSDR (2004), and ACGIH (7th, 2001), and that mild respiratory irritation was observed in human exposure example in ATSDR (2004), it was classified into Category 3.
9 Specific target organ toxicity - Repeated exposure Category 1 (central nervous system, liver, heart), Category 2 (lung) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (central nervous system, liver, heart)
H373: May cause damage to organs through prolonged or repeated exposure (lung) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In CERI Hazard Data (1998), EHC 136 (1992), ACGIH (7th, 2001), PATTY (4th, 1994), IARC 71 (1999), industrial hygene academic society advice (1974), and ATSDR (2004), there is the description that central nervous system manifestations is observed by the human repeated exposure, there is the description that the arrhythmia was observed in the example of the human repeated exposure in ATSDR (2004), and there is the description that liver damages were observed for the example of the human repeated exposure in EHC 136 (1992), IARC 71 (1999), and ATSDR (2004), due to above resutls it is considered that target organs were central nervous system, heart and liver, and they all were classified into Category 1. Furthermore, it was classified into Category 2 due to the description that the lung change was observed to the guinea pig by moderate level inhalation in CERI Hazard Data (1998) and ACGIH (7th, 2001).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 24-hour LC50=8000microg/L of Crustacea (Brine shrimp) (MOE Risk Assessment No.2, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 2, since acute toxicity was Category 2 and not rapidly degrading (BOD: 0% (existing chemical safety inspections data)), though less bio-accumulative (BCF=4.9 (existing chemical safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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