GHS Classification Result

Chemical Name:Fenitrothion
CAS:122-14-5

Result:
ID: 154
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Classification not possible - - - - Insufficient data available
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Flash point: >93degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - No data available
9 Pyrophoric liquids Not classified - - - - The flash points is 157 degC (ICSC (J) (1996)), and even if it contacts the normal temperature air, it does not ignite.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Classification not possible - - - - Insufficient data available
13 Oxidizing liquids Classification not possible - - - - Insufficient data available
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Calculated based on rat LD50 value: 330mg/kg, 415mg/kg, 1700mg/kg, and 660mg/kg (all are Agricultural-Chemicals abstracts). Since the calculation values were lower than these lowest values, 330mg/kg was adopted and was set as Category 4.
1 Acute toxicity (Dermal) Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Based on rat LD50 value: 1260mg/kg and 2700mg/kg (all are Agricultural-Chemicals abstracts), the value of the lower one was adopted and it was set as Category 4.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Rat LC50 (4 hours) value was >2.210mg/L (Agricultural-Chemicals abstracts). But Category could not be specificked, it cannot classify since data is insufficient.
2 Skin corrosion/irritation Not classified - - - - Since no irritant effect was seen in the test on rabbits (Agricultural-Chemicals abstracts), it was classified as out of Category.
3 Serious eye damage/eye irritation Not classified - - - - Since change which suited to acceptance criteria of irritation by the test using a rabbit was not admitted (Agricultural-Chemicals abstracts), it was set as the outside of Category.
4 Respiratory sensitization Not classified - - - - Classified as out of category because the systemic exposure test using guinea pigs judged that this had no allergic asthma-inducing effect (agrochemical abstract).
4 Skin sensitization Not classified - - - - Classified as out of category because the Landsteiner & Draize method test using guinea pigs judged skin sensitization as negative (agrochemical abstract).
5 Germ cell mutagenicity Not classified - - - - The substance was regarded as outside the categories. Because there are negative results from dominant lethal tests using rats and mice, and there are negative results from the chromosome aberration tests using mammalian bone-marrow cells, which are in vivo mutagenicity tests using somatic cells, and micronucleus tests (both from Agricultural-Chemicals abstracts).
6 Carcinogenicity Not classified - - - - Since it was classified into Group E according to EPA, it was set as the outside of Category.
7 Reproductive toxicity Not classified - - - - There is no bad effect to the reproductive function, the reproductive potential, and the development of neonatal in the three generation breeding test of rats, and in the administration test during pregnancy using rat and mouse (all are from Agricultural-Chemicals abstracts). So it was considered as on the outside of Categry.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
By oral, transdermal and inhalation exposures tests using rat and dog, the symptoms which indicates the effects on the nervous systems, and the inhibitions of plasma, blood cells and brain cholinesterase activity were observed in the dosage range of the guidance value of Category 1 (all were Agricultural-Chemical abstracts). So it was classified into Category 1(nervous systems).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In the six-month feeding oral administration tests using rat and rabbit, and in inhalation exposure test using rat and mouse, since the inhibition of the activity of plasma, blood cell, and brains cholinesterase was observed by exposure of the guidance value range of Category 1 (all are Agricultural Chemicals abstracts), it was classified into Category 1 (nervous systems).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 96-hour LC50=0.0015mg/L of Crustacea (Northern Brown shrimp) (EHC133, 1992).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity was Category 1, not rapidly degrading (BOD: 0% (existing chemical safety inspections data)), though less bioaccumulative (BCF=101.7 (existing chemical safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


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