Chemical Name：O,O-diethyl O-(1,6-dihydro-6-oxo-1-phenylpyridazin-3-yl) thiophosphate
CAS：119-12-0

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	SPECIES: Rat (female) ENDPOINT: LD50 VALUE: 813 mg/kg REFERENCE SOURCE: Agricultural Chemicals abstracts
1	Acute toxicity （Dermal）	Category 5	-	Warning	H313: May be harmful in contact with skin	P312: Call a POISON CENTER or doctor/physician if you feel unwell.	It was set as Category 5 based on rat (female) LD50 value: 2100mg/kg (Agricultural-Chemicals abstracts).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	Rat LC50 (4 hours) value is >1.1333mg/L (Agricultural-Chemicals abstracts), the category could not be specified only by this data. Therefore, it cannot be classified since data is insufficient.
2	Skin corrosion/irritation	Not classified (40% emulsion)	-	-	-	-	Since erythema and edema were not observed in the skin irritation test on rabbits with 40% emulsion (Agricultural-Chemicals abstracts), it was classified as out of Category.
3	Serious eye damage/eye irritation	Not classified	-	-	-	-	Since eye irritation was not admitted in the eye irritation test using a rabbit (Agricultural-Chemicals abstracts), it was set as the outside of Category.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data
4	Skin sensitization	Not classified	-	-	-	-	Classified as out of category because the topical allergy tests using guinea pigs resulted negative (agrochemical abstract).
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	The substance cannot be classified because there are only negative data from in vitro tests (three kinds of tests) (Agricultural-Chemicals abstracts).
6	Carcinogenicity	Not classified	-	-	-	-	Any organization had classified for carcinogenicity. But generating of tumors relevant to administration was not observed in the chronicity and the carcinogenicity test using rats and mice (Agricultural-Chemicals abstracts). So it was set as the outside of Category.
7	Reproductive toxicity	Not classified	-	-	-	-	There were no obvious reproductive toxicity in the dose causing general toxicity to parent animals in the peroral administration breeding toxicity test using rat, and in the teratogenicity test using rat and rabbit (Agricultural-Chemicals abstracts). So it was considered as on the outside of Categry.
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system), Category 2 (gastrointestinal tract, eye)		Danger Warning	H370: Causes damage to organs (nervous system) H371: May cause damage to organs (gastrointestinal tract, eye)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.	Due to the descriptions that neurological symptoms, eye nebula and gastrointestinal ulcers were observed in the dosage range of the guidance value of Category 2 in the oral study using rat (Agricultural-Chemical abstracts), and that the effects on the nervous system was observed in the dosage range of the guidance value of Category 1in the inhalation exposure test using rat. So they were classified into Category 1 (nervous system) and 2 (eyes, digestive tracts).
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (nervous system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	In the 13-week feeding oral administration tests using rat, since decrease in brains cholinesterase activities was observed with the given dose of the guidance value range of Category 1 (Agricultural Chemicals abstracts), it was classified into Category 1 (nervous systems).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 48-hour EC50=0.00051mg/L of Crustacea (Daphnia magna) (MOE eco-toxicity tests of chemicals, 1997).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though less bioaccumulative (BCF=46 (existing chemical safety inspections data)).