GHS Classification Result

Chemical Name：Malathon
CAS：121-75-5

Result：
ID: 143
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Flash point: >93degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - The flash points is 163 degC (HSDB, 2006), and even if it contacts air in room temperatures, it does not ignite.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Classification not possible - - - - Insufficient data available
13 Oxidizing liquids Classification not possible - - - - Insufficient data available
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Although there is information that it corrodes iron and other metals (HSDB, 2006), since data is insufficient.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		SPECIES: Rat ENDPOINT: LD50 VALUE: 1390 mg/kg REFERENCE SOURCE: Agricultural Chemicals abstracts
1 Acute toxicity （Dermal） Not classified - - - - It was set as the outside of Category. Since rat LD50 value = >5000mg/kg and death is not observed in 5000mg/kg or less (Agricultural-Chemicals abstracts).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Since the category can not be specified only by the data (Agricultural-Chemicals abstracts) that rat LC50 (4 hours) value is >3.450mg/L, it cannot be classified.
2 Skin corrosion/irritation Not classified - - - - Since no local reactions was seen in the test on rabbits (Agricultural-Chemicals abstracts), it was classified as out of Category.
3 Serious eye damage/eye irritation Not classified - - - - Since change applicable to the stimulative judging standard indicated in the technical indicator by the test using a rabbit was not admitted (Agricultural-Chemicals abstracts), it was set as the outside of Category.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Neither contact allergy nor optical allergy was found in human patch tests and photopatch tests. However we classified this Category 1 because the Maximization method test using guinea pigs showed more than 30% of positive rate (agrochemical abstract).
5 Germ cell mutagenicity Not classified - - - - The substance was regarded as outside the categories because the result of the micronucleus test using mouse bone-marrow cells, which is an in vivo mutagenicity test using somatic cells, is negative (Agricultural-Chemicals abstracts).
6 Carcinogenicity Not classified - - - - Since it is classified into a group 3 (IARC Suppl.7, 1987) according to IARC and was classified into A4 (ACGIH 7th, 2001) according to ACGIH. So it was set as the outside of Category.
7 Reproductive toxicity Not classified - - - - The reproductive function, reproductive ability, and the bad effect to a child's generating were not admitted by three-generation breeding examination using rat, and medication examination during the pregnancy using rat and rabbit (Agricultural-Chemicals abstracts). So it was considered as on the outside of Categry.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since there was description that the symptom which indicates the effects on the nervous systems in WHO"Recommended health-based limits in occupational exposure to pesticides"as the human acute toxicity symptoms (Agricultural-Chemical abstracts), it is considered that the nerve is target organ. Therefore, it was classified into Category 1 (nervous systems).
9 Specific target organ toxicity - Repeated exposure Not classified - - - - Since significant toxicity was not observed in the oral study using rat, mouse and dog, and the repeated oral administrations to human (Agricultural Chemicals abstracts), it was carried out the out of Category.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 48-hour EC50=0.72microg/L of Crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2005).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity was Category 1, not rapidly degrading (BOD: 22% (existing chemical safety inspections data)), though supposed less bioaccumulative (log Kow=2.36 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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