GHS Classification Result

Chemical Name：Dichloromethane; Methylene dichloride
CAS：75-09-2

Result：
ID: 141
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no atom groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Classification not possible - - - - Cannot be classified due to varied information on the flammability - e.g., "combustible under specific conditions," (explosion limit: 12-25 vol%), according to ICSC (2004), and "no flashing point," according to NFPA (13th, 2002). Classified into Category 6.1 (UN Recommendations on the Transport of Dangerous Goods, UN#1593)
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Containing no atom groups with explosive or self-reactive properties
9 Pyrophoric liquids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the flashing point is 556degC (ICSC, 2004)
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing chlorine (but not oxygen and fluorine), with the chlorine bound to carbon and hydrogen (but not to other elements)
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to gaseous substances are not available - boiling point: 40degC (ICSC,2004), test temperature: 55degC

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the rat LD50 (oral route) value of 1,600mg/kg representing the lower of the two testing data, 2,100mg/kg (CERI Hazard Data 96-2, 1997) and 1,600mg/kg (MOE Risk Assessment Vol.2, 2003).
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Not classified - - - - Based on the LC50 value (4 hours) of 64mg/L (18,000ppm), calculated from the testing data of rat LC50 (6 hour inhalation exposure) of 53mg/L (CERI-NITE Hazard Assessment No.15, 2004), was lower than 90% of the saturated vapor concentration (570,000 ppm) under a saturated vapour pressure of 58 kPa (25degC), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on the evidence of "moderate irritation but no skin corrosion observed" from rabbit skin irritation tests (CERI-NITE Hazard Assessment No.15, 2004).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the evidence of "moderate or severe eyelid irritation" from rabbit eye irritation tests (CERI-NITE Hazard Assessment No.15, 2004).
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Not classified - - - - Based on negative data on heritable mutagenicity tests (dominant lethal tests) and somatic cell mutagenicity tests in vivo (micronucleus/chromosome aberration tests) and the absence of germ cell mutagenicity tests in vivo, described in CERI-NITE Hazard Assessment No.15 (2004), IARC 71 (1999) and EHC 164 (1996). One testing agency reported that the substance was weakly positive for inhalation toxicity in micronucleus, chromosome aberration and SCE tests in mice, but the responses were weak and considered ambiguous and indecisive in EHC 164 (1996) and thus was not considered "positive".
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Due to the fact that the substance is classified as Category R by NTP (2005), Group 2B by IARC (1999), Category A3 by ACGIH (2001) and Category B2 by EPA (1993).
7 Reproductive toxicity Classification not possible - - - - Insufficient data available
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system, respiratory system), Category 3 (narcotic effects) Danger
Warning 		H370: Causes damage to organs (central nervous system, respiratory system)
H336: May cause drowsiness or dizziness (narcotic effects) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Suppression of the central nervous system, such as cyanosis, headaches, chest pains, disturbance of consciousness, progressive vigilance disturbance, increased fatigue, lethargy, memory loss and loss of time sensation, and decreased critical flicker frequency as a measure for sensory function have been observed, and then neurobehavioural effects, such as diffused vigilance and impaired combined tracking monitoring performance, and other effects such as inflammation of the skins and lung with sclerosis, lung edema with bleeding, and cerebral edema with tonsillar herniation have been observed as acute toxicity symptoms in humans (CERI-NITE Hazard Assessment Report No.15 (2004)). Moreover, there have been adverse reports such as necrosis of the epithelial cells in the bronchi and bronchioles, swollen and vacuolated Clara cells, mildly increased cell divisions and changes in somatosensory evoked responses and EEG(CERI-NITE Hazard Assessment Report No.15 (2004)) within the guidance values for Category 2 in the single-dose studies. Based on these effects, the centralnervous system and respiratory organs are considered to be the target organs. Therefore, the substance was classified as Category 1 (central nervous system, respiratory organs) and Category 3 (narcotic effects).
9 Specific target organ toxicity - Repeated exposure Category 1 (central nervous system, liver) Danger H372: Cause damage to organs through prolonged or repeated exposure (central nervous system, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "intermittent headache, nausea, flickering vision, breathlessness, temporary memory disorder and right brain damage found in electroencephalography" (CERI-NITE Hazard Assessment No.15, 2004) and "cerebropathy associated with auditory/visionary hallucinations after exposure", "memory disorder associated with intellectual impairment, loss of balance, temporary bilateral degeneration of temporal lobe" (HSDB, 2000) and the evidence from animal studies including "hepatocytes positively stained for fat, mild vacuolation of hepatocytes" and "mutant hepatocytes" (CERI-NITE Hazard Assessment No.15, 2004). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 48 hours LC50=27mg/L of Crustacea (Daphnia magna) (CaPSAR, 1993).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since it was highly volatile and diffused rapidly into the air, and the bio-accumulation was low (BCF=40 (Existing Chemical Safety Inspections Data)), it was classified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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