GHS Classification Result

Chemical Name：3,3'-Dichlorobenzidine
CAS：91-94-1

Result：
ID: 138
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available by regulated examination methods, though "Flammable" (ICSC (J) (1994))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Flash point: 350degC (ICSC (J), 1994)
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing chlorine (but not oxygen and fluorine) and the chlorine is chemically bonded only to carbon and hydrogen (but not to other elements).
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on Rat LD50 value =7070mg/kg (CERI Hazard Data (2002), MOE Risk Assessment the 3rd volume (2004), IARC 29 (1982), ATSDR (1998) and about 7000mg/kg (ACGIH (7th, 2001)), it was set as the outside of Category.
1 Acute toxicity （Dermal） Not classified - - - - Based on rabbit LD50 value =>8000mg/kg (CERI Hazard Data (2002)) and rabbit minimum lethal dose =>8000mg/kg (ATSDR (1998)), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - There are a report that dermatitis with human occupational exposure (sources are limited to two reports) (the 3rd volume of MOE Risk Assessment(2004), CICAD 2 (1998), IARC 29 (1982), and ATSDR (1998)), and the potential skin sensitizations is suggested to be the cause of dermatitis (ATSDR (1998)). There is a data which suggests the possibility of primary skin irritation being low (CERI Hazard Data (2002)). But there is no animal data proving these, and data is insufficient, it cannot be classified.
3 Serious eye damage/eye irritation Not classified - - - - From description that even if applied to the rabbit eye, irritation was not seen (CERI Hazard Data (2002), CICAD 2 (1998), and ATSDR (1998)), and there was no report which indicated the eye irritation in the example of human exposure. So it was set as the outside of Category.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - CERI Hazard Data (2002), MOE Risk Assessment vol. 3 (2004), CICAD 2 (1998), IARC 29 (1982) and ATSDR (1998) describe that dermatitis was found in the cases of human occupational exposures. However this is uncategorizable because of insufficient data for judging whether it is induced by irritation or sensitization.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The substance was classified as Category 2. Because there are positive results from the chromosome aberration test using mammalian bone-marrow cells, which is an in vivo mutagenicity test using somatic cells, and the micronucleus test using mammalian erythrocytes (CERI Hazard Data (2002), CICAD 2(1998), ATSDR(1998)), and there are no positive results from in vivo genotoxicity tests in germ cells.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It is classified into the category 2 in EU. But it is classified into B-2 according to IARC and Japan Society for Occupational Health, into A3 according to ACGIH, B2 according to EPA, and into R according to NTP. So it was set as Category 2.
7 Reproductive toxicity Classification not possible - - - - No data available
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is the descriptions that it causes moderate pneumoemia (some irritation and moderate pulmonary congestion) by inhalation exposure to rat in ACGIH (7th, 2001), that the throat pain frequency is high in human exposure evidence in CERI Hazard Data Description (2002), and that it stimulates human respiratory tracts by short-term exposure in the 3rd volume of MOE Risk Assessment (2004). Therefore, it was classified into Category 3 (respiratory irritant).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Classification not possible due to lack of data
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96-hour 0.5mg/L of fishes (Bluegill), and others (CaPSAR, 1993).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity was Category 1, not rapidly degrading (BOD: 1% (existing chemical safety inspections data)), though less bioaccumulative (BCF=213 (existing chemical safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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