NITE - Chemical Management Field

GHS Classification Result

Chemical Name：1,2-Dichloroethylene
CAS：540-59-0

Result：


ID:	128
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	Containing no atom groups with explosive properties
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
5	Gases under pressure	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
6	Flammable liquids	Category 2		Danger	H225: Highly flammable liquid and vapour	P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ...	The flashing points are 6degC for cis-dichloroethylene and 2-4degC for trans-dichloroethylene (ICSC, 2003) (closed cup flash test); the boiling point is 55degC -- which is classified into Category 2, or Class 3 and Container II (UN#1150, UN Recommendations on the Transport of Dangerous Goods)
7	Flammable solids	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
8	Self-reactive substances and mixtures	Not classified	-	-	-	-	No data available, though containing unsaturated bonds. Classified into Class 3 (UN#1150) by UN Recommendations on the Transport of Dangerous Goods.
9	Pyrophoric liquids	Not classified	-	-	-	-	Not pyrophoric when in contact with air at ordinary temperatures: the flashing point is 460degC (ICSC,2003)
10	Pyrophoric solids	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid substances are not available
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13	Oxidizing liquids	Not applicable	-	-	-	-	Organic compounds containing chlorine (but not oxygen and fluorine), with the chlorine bound to carbon and hydrogen (but not to other elements)
14	Oxidizing solids	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no "-O-O-" structure
16	Corrosive to metals	Not classified	-	-	-	-	Classified into Class 3 (UN#1150) by UN Recommendations on the Transport of Dangerous Goods

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 5	-	Warning	H303: May be harmful if swallowed	P312: Call a POISON CENTER or doctor/physician if you feel unwell.	Based on the LD50 value of 2,080mg/kg calculated from the testing data of rat LD50 (oral route) of 1,275mg/kg (ACGIH 7th, 2001), 7,900mg/kg (ATSDR, 2001) and 10,000mg/kg (ATSDR, 2001) using trans-1,2-dichloroethylene, although no data were available for 1,2-dichloroethylene (mixture).
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Not classified	-	-	-	-	Based on the LC50 (4 hours) value of 26,610ppm, calculated from the testing data of mouse LC50 (inhalation of vapour) of 86.24 mg/L (6 hours) (ACGIH 7th, 2001) obtained using trans-1,2-dichloroethylene, was lower than 90% of the saturated vapor concentration (238,000ppm) under a saturated vapour pressure of 180 Torr (20degC) (ACGIH 7th, 2001), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm, although no data were available for 1,2-dichloroethylene (mixture).
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available
2	Skin corrosion/irritation	Category 2		Warning	H315: Causes skin irritation	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse.	Based on the evidence of "moderate irritation" from the rabbit skin irritation test using trans-1,2-dichloroethylene (CERI Hazard Data 2000-46, 2001), although no data were available for 1,2-dichloroethylene (mixture).
3	Serious eye damage/eye irritation	Category 2A		Warning	H319: Causes serious eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection.	Based on the evidence of "moderate irritation" from the rabbit eye irritation test using trans-1,2-dichloroethylene (CERI Hazard Data 2000-46, 2001), although no data were available for 1,2-dichloroethylene (mixture).
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Classification not possible	-	-	-	-	No data available
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on the absence of positive data on heritable/germ-cell in vivo mutagenicity tests and the presence of negative data on somatic cell mutagenicity tests in vivo, described in NTP TOX55 (2002).
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available
7	Reproductive toxicity	Classification not possible	-	-	-	-	No data available
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system)		Danger	H370: Causes damage to organs (central nervous system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the human evidence including "nausea, vomiting, tremor, oppressing feeling in the upper abdomen and depression of the central nervous system" (CERI Hazard Assessment 2000-46, 2001) and the evidence from animal studies including "a 45% loss of swimming capability" (ATSDR, 1996). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
9	Specific target organ toxicity - Repeated exposure	Category 2 (blood system)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (blood system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Based on the evidence from animal studies including "marked decreases in complete blood counts, red blood cell counts, hemoglobin levels and hematocrit values" (ATSDR, 1996). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 2	-	-	H401: Toxic to aquatic life	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	It was classified into Category 2 from 24 hours LC50=0.07mmol/L of the crustacea (Brine Shrimp) (AQUIRE, 2003).
11	Hazardous to the aquatic environment （Long-term）	Category 2		-	H411: Toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Although acute toxicity was Category 2 and the bio-accumulation potential was low (log Kow=2(PHYSPROP Database, 2005)), since there was no rapidly degrading (the decomposition by BOD: 0%(HSDB, 2004)), it was classified into Category 2.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）