GHS Classification Result

Chemical Name:1,2-Dichloroethane
CAS:107-06-2

Result:
ID: 126
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
The flash point is 13degC (c.c.) (ICSC, 1999) and the boiling point is 83.5degC, which is classified into Category 2. Classified into Class 3 and Division 6.1 (UN#1184) (UN Recommendations on the Transport of Dangerous Goods)
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures; the auto-ignition temperature is 413degC (ICSC, 1999)
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing chlorine (but not oxygen and fluorine), with the chlorine bound to carbon and hydrogen (but not to other elements)
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Not classified - - - - Classified into Class 3 and Division 6.1 (UN#1184) (UN Recommendations on the Transport of Dangerous Goods)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on the LD50 value of 695mg/kg calculated from the testing data of rat LD50 (oral route) of 680mg/kg (EHC 62, 1987), 850mg/kg (EHC 62, 1987) and 967mg/kg (SIDS, 2002).
1 Acute toxicity (Dermal) Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. Based on the testing data of rabbit LD50 (dermal route) of 4,890mg/kg (SIDS (2002)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the LC50 value (4 hours) of 1,000ppm, calculated from the testing data of rat LC50 (inhalation of vapour) of 4 mg/L (6 hours) (EHC 62 (1987)), 6.6mg/L (7.25 hours) (EHC 62 (1987)), 3.29mg/L (10 hours) (SIDS (2002)), and 6.77mg/L (6 hours) (SIDS (2002)), was lower than 90% of the saturated vapor concentration (80,500ppm) under a saturated vapour pressure of 8.13kPa (20degC) (CERI Hazard Data 96-20 (1997)), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
Based on the description in the report on rabbit skin irritation tests (CERI-NITE Hazard Assessment No.3 (2004)): "moderate irritant."
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
Based on the description in the report on human epidemiological studies and rabbit eye irritation tests (CERI-NITE Hazard Assessment No.3 (2004): The results of Draize tests suggest "mild irritation."
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on negative data on multi-generation mutagenicity tests (dominant lethal tests), the absence of data on germ cell mutagenicity tests in vivo, positive data on somatic cell mutagenicity tests in vivo (mouse spot tests), and the absence of data on germ cell genotoxicity tests in vivo, described in SIDS (2004), IARC 71 (1999), CERI-NITE Hazard Assessment No.3 (2004), and EHC 176 (1995), according to the technical guideline (Appendix 1).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Due to the fact that the substance is classified as Group 2B by IARC (1999), Category B2 by IRIS (2005), and Category R by NTP (2005).
7 Reproductive toxicity Not classified - - - - Based on the description in CERI-NITE Hazard Assessment No.3 (2004): Reproductive mouse toxicity tests, rat one-generation tests and rat and rabbit teratogenicity tests show no effects on the embryo.
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system, liver, kidney, adrenal gland), Category 3 (narcotic effects) Danger
Warning
H370: Causes damage to organs (central nervous system, liver, kidney, adrenal gland)
H336: May cause drowsiness or dizziness (narcotic effects)
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
Based on the human evidence including "crouching position, confusion, staggering gait, hyperkinesias, tremor, somnolency, clouding of consciousness, coma, hemorrhagic diathesis, cyanosis, hepatic necrosis, tubulonecrosis, adrenal necrosis, circulatory system disorder" (CERI-NITE Hazard Assessment No.3 (2004)).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, liver, thyroid), Category 2 (kidney) Danger
Warning
H372: Cause damage to organs through prolonged or repeated exposure (nervous system, liver, thyroid)
H373: May cause damage to organs through prolonged or repeated exposure (kidney)
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the human evidence including "neurosis, myeloradiculitis, hepatic disease, cholepathia, autonomic ataxia, bronchocele, hyperthyroidism, inertia" (CERI-NITE Hazard Assessment No.3 (2004)), and the evidence from animal studies including "reversible degeneration of the renal tubular epithelium" (CERI-NITE Hazard Assessment No.3 (2004)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
10 Aspiration hazard Category 1 Danger H304: May be fatal if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the description in the report on human symptoms: "May cause pulmonary edema if inhaled and chemical pneumonia if swallowed." (MOE Risk Assessment vol. 2 (2003)), "Pulmonary congestion/edema, dyspnea and bronchitis were observed in deceased patients (due to acute ingestion), while pulmonary edema can be attributed to chemical pneumonia due to misswallowing" (ATSDR (2001)).

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 3 from 96-hour LC50=94mg/L of the fish (Bluegill) (SIDS (2004) and others.).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Although the acute toxicity was Category 3, judging from NOEC=29000microg/L during 28 days of the fish (Fathead minnows) (MOE Risk Assessment vol. 2, 2003), it was classified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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