GHS Classification Result

Chemical Name：3-Chloropropene; Allyl chloride
CAS：107-05-1

Result：
ID: 116
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		The flash point is -32degC (c.c.) (ICSC, 2004) and the boiling point is 45degC which is classified into Category 2. Classified into Class 3 and Division 6.1 (UN#1100) (UN Recommendations on the Transport of Dangerous Goods)
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not classified - - - - No data available, though containing unsaturated bonds. Classified into Class 3 and Division 6.1 (UN#1100) (UN Recommendations on the Transport of Dangerous Goods)
9 Pyrophoric liquids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 390degC (ICSC, 2004)
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing chlorine (but not oxygen and fluorine), with the chlorine bound to carbon and hydrogen (but not to other elements)
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to gaseous substances are not available - boiling point: 45degC (ICSC, 2004), test temperature: 55degC

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the testing data of rat LD50 (oral route) of 450mg/kg (SIDS (2003)).
1 Acute toxicity （Dermal） Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. Based on the testing data of rat LD50 (dermal route) of 2,026mg/kg (SIDS (2003)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the LC50 value (4 hours) of 7.8mg/L (2,500ppm), calculated from the testing data of rat LC50 (2-hour inhalation) of 11mg/L (MOE Risk Assessment vol. 2 (2003)), was lower than 90% under of the saturated vapour concentration (389,000ppm) under a saturated vapour pressure of 39.3kPa (20degC), the substance was classified based on standard values expressed in ppm.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description in the report on animal skin irritation tests (SIDS (2003), CERI Hazard Data 98-26 (1999)): Mild irritation and damage to the skin are observed. And based on the data on human health effects (CERI Hazard Data 98-26 (1999)): Severe burn and pain are observed (the intensity of irritation is unknown, while the substance is corrosive to the skin), although the substance should be placed in Category 1A from the viewpoint of safety, if further subclassification is needed.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Based on the description in the report on animal eye irritation tests (CERI Hazard Data 98-26 (1999), SIDS (2003)): Mild irritation is observed. And based on the data on human health effects (ACGIH (7th, 2001)): Severe irritation associated with pain and corneal injury is observed, which may cause vision loss. The substance could cause irreversible irritation to the eyes.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Not classified - - - - Based on the negative data on multi-generation mutagenicity tests, the absence of data on germ cell mutagenicity tests in vivo, and negative data on somatic cell mutagenicity tests in vivo (chromosome aberration tests), described in SIDS (2003), NTP DB (Access on February 2006) and IARC 71 (1999).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Due to the fact that the substance is classified as Category A3 by ACGIH (2001).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description in CERI Hazard Data 98-26 (1999): Malformations such as a hernia of the umbilical cord are observed in offspring at dosing levels toxic to dams; sperm abnormalities are observed, though no description is available for the general toxicity to parental animals.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system, nervous system, kidney, liver, heart), Category 3 (narcotic effects) Danger
Warning 		H370: Causes damage to organs (respiratory system, nervous system, kidney, liver, heart)
H336: May cause drowsiness or dizziness (narcotic effects) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on the human evidence including "pulmonary edema (CERI Hazard Data 98-26 (1999)), and the evidence from animal studies including "nervous symptoms (a decrease in mobility, lethargy, dyspnea, paralysis of the hind limbs, tremor, convulsions, etc.), histologic damage to the kidneys and liver, degeneration of the heart muscle and hepatocytes, irritation to the mucous, narcotic influence, pulmonary congestion/hemorrhage/edema" (CERI Hazard Data 98-26 (1999)). The effects on experimental animals were observed at dosing levels within the ranges for Category 1.
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, kidney, heart, liver) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system, kidney, heart, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "debility, paresthesia, distal paralysis" (MOE Risk Assessment vol. 2 (2003)), "renal toxicity caused by chronic exposure (reduction of the membrane permeability of the glomeruli, renal tubular degeneration, oliguresis, pain on urination, nycturia), neuropathy (tremor of the hands and eyelids, an increase in tendon/periosteal reflexes, polyhidrosis, reduced body temperature, cyanosis, somnipathy, paresthesia in the hands and feet), adverse effects on the cardiovascular system (a decrease in myocardial contraction, reduction in the intensity of heart sounds, cardiac murmur, cardiodynia), changes in the hepatic function" (CERI Hazard Data 98-26 (1999)), and the evidence from animal studies including "hepatic sinusoidal expansion, hepatocyte swelling, focal necrosis, degeneration of the glomeruli, necrosis of the renal tubular epithelium, interstitial growth, degeneration of the peripheral nerves" (CERI Hazard Data 98-26 (1999)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 96 hours TLm=19780microg/L of the fish (Fathead Minnows) (MOE Risk Assessment vol. 3, 2004).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since there was rapidly degrading (the decomposition by BOD: 62% (Existing Chemical Safety Inspections Data)) and the bio-accumulation was low (BCF=5.6 (Existing Chemical Safety Inspections Data)), it was claasified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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