GHS Classification Result

Chemical Name：Chloroethylene; Vinyl chloride
CAS：75-01-4

Result：
ID: 113
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Classified as "gas" according to GHS definition
2 Flammable gases （including chemically unstable gases） Category 1 Danger H220: Extremely flammable gas P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P377: Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P381: Eliminate all ignition sources if safe to do so.
P403: Store in a well-ventilated place. 		Based on the description in ICSC (2000): the lower explosion limit is 3.6vol%. Those containing stabilizers are classified into Division 2.1 (UN Recommendations on the Transport of Dangerous Goods, UN#1086)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Classification not possible - - - - No data available Those containing stabilizers are classified into Division 2.1 (UN Recommendations on the Transport of Dangerous Goods, UN#1086)
5 Gases under pressure Liquefied gas Warning H280: Contains gas under pressure; may explode if heated P410+P403: Protect from sunlight. Store in a well-ventilated place. The boiling point is -13degC (ICSC 2000), and the critical temperature is 151.5degC (HSDB 2005) - i.e., liquefied gas. Those containing stabilizers are classified into Division 2.1(UN#1086) (UN Recommendations on the Transport of Dangerous Goods)
6 Flammable liquids Not applicable - - - - Classified as "gas" according to GHS definition
7 Flammable solids Not applicable - - - - Classified as "gas" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Classified as "gas" according to GHS definition
9 Pyrophoric liquids Not applicable - - - - Classified as "gas" according to GHS definition
10 Pyrophoric solids Not applicable - - - - Classified as "gas" according to GHS definition
11 Self-heating substances and mixtures Not applicable - - - - Classified as "gas" according to GHS definition
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Classified as "gas" according to GHS definition
13 Oxidizing liquids Not applicable - - - - Classified as "gas" according to GHS definition
14 Oxidizing solids Not applicable - - - - Classified as "gas" according to GHS definition
15 Organic peroxides Not applicable - - - - Classified as "gas" according to GHS definition
16 Corrosive to metals Classification not possible - - - - Test methods applicable to gaseous substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - Insufficient data available
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not classified - - - - Based on the testing data of rat LC50 (inhalation of gas) of 108,102ppm (SIDS (2001)).
1 Acute toxicity （Inhalation: Vapours） Not applicable - - - - Due to the fact that the substance is "gas" according to the GHS definition and inhalation of its vapour is not expected.
1 Acute toxicity （Inhalation: Dusts and mists） Not applicable - - - - Due to the fact that the substance is "gas" according to the GHS definition and inhalation of its dust/mist is not expected.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on the description on human health effects (EHC 215 (1999)) "erythema and some second-degree burns which healed without complication."
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Based on the description in EHC 215 (1999) of human health effects: The substance is considered to cause mild, reversible irritation to the eyes.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on negative data on germ cell multi-generation mutagenicity tests in vivo (dominant lethal tests), the absence of data on germ cell mutagenicity tests in vivo, positive data on somatic cell mutagenicity tests in vivo (chromosome aberration tests, micronucleus tests), and the absence of data on germ cell genotoxicity tests in vivo, described in CERI-NITE Hazard Assessment No.75 (2004), ATSDR (2004).
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Due to the fact that the substance is classified as Category A1 by ACGIH (2001), Group 1 by IARC (1987), Category A by EPA (2000), Category K by NTP (2005), and Category 1 by the Japan Society for Occupational Health.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description in the report on inhalation exposure tests on male rats (CERI-NITE Hazard Assessment No.75 (2004)): Morphologic changes in the testes and a decrease in its relative weight are observed, though no description is available for general toxicity.
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system), Category 3 (narcotic effects) Danger
Warning 		H370: Causes damage to organs (central nervous system)
H336: May cause drowsiness or dizziness (narcotic effects) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on the human evidence including "confusion, headache, dizziness, euphoria, intoxication, narcotic influence, somnolency after working hours, hypersomnia" (CERI Hazard Data 96-10 (1997)).
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, nervous system, respiratory system, testis) Danger H372: Cause damage to organs through prolonged or repeated exposure (liver, nervous system, respiratory system, testis) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "hepatic hypertrophy, hepatic fibrosis, portal hypertension, splenic hypertrophy, dizziness, misty vision, tingling sensation in the hands and feet, cold hands and feet, neuropathy including sensorimotor polyneuropahty, the trigeminal nerve sensory neurosis, mild pyramidal tract syndrome, cerebral ataxia, extrapyramidal motor nerve disorder, nervous debility, depression, changes in EEG, pulmonary emphysema, pulmonary fibrosis, Reynaud's phenomenon, osteolysis of the epiphysis of the hands and feet, scleroderma" (CERI-NITE Hazard Assessment No.75 (2004)), and the evidence from animal studies including "a significant increase in pleomorphic hepatocytes, an increase in hepatic cysts, hepatocyte necrosis, proliferation of Kupffer cells, seminiferous tubule damage, necrosis of the seminiferous epithelia, necrosis, impaired spermatogenic ability associated with giant multinucleate syncytial cells" (CERI-NITE Hazard Assessment No.75 (2004)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Not applicable - - - - Not applicable

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 24 hours LC50=80.7mg/L of the crustacea (Daphnia magna) (EHC215, 1999).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Although acute toxicity was Category 3 and the bio-accumulation potential was low (log Kow=1.46(Existing Chemical Safety Inspections Data)), since there was no rapidly degrading (the decomposition by BOD: 3%(Existing Chemical Safety Inspections Data)), it was classified into Category 3.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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