GHS Classification Result

Chemical Name：Atrazine
CAS：1912-24-9

Result：
ID: 112
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - Although ICSC (J) (1994) has the description "it is a flammable under specific conditions", there is no test data and it cannot be classified.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-pyrophoric when in contact with air at a room temperature and used as agricultural chemicals.
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing chlorine and the chlorine is chemically bonded only to carbon (but not to other elements).
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available. Non-corrosive to metals (HSDB, 2004)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		The higher toxicity (female 3000mg/kg) was adopted among male LD50 = 3520 mg/kg and female 3000 mg/kg of the oral administration examination using a rat (Agricultural Chemical Registration Data, 2002), and it was set as Category 4.
1 Acute toxicity （Dermal） Not classified - - - - It was set as the outside of Category. Since fatal cases was not seen 5000mg/kg in rat dermal administration test LD50 >2000mg/kg (Agricultural Chemical Registration Data, 2002) and >5000 mg/kg (Agricultural Chemical Registration Data, 1987).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 5 - Warning H333: May be harmful if inhaled P304+P312: IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. In both LC50 >5.82mg/L (Agricultural Chemical Registration Data, 2002) and >5.148mg/L (Agricultural Chemical Registration Data, 1991) of an inhalation exposure test using rats, no death cases were repoted. But the oral acute toxicities of category 4 were indicated, it was set as Category 5. In addition, the saturated concentration of this product is 3.81*10^(-4)ppm (equivalent 3.36*10^(-6)mg/L), and it is presumed that all inhalation tests are done in dust mists conditions.
2 Skin corrosion/irritation Not classified - - - - Since irritation was not observed in the rabbit skin primary irritation test with 50% hidrated agent was classified as in GLP (Agricultural Chemical Registration Data, 1989), it was classified as out of Category.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Since mild irritation was admitted in the rabbit eye membrane primary irritation examination by the 50% wettable powder carried out in GLP (Agricultural Chemical Registration Data, 1989), it was set as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Classified as Category 1 because positive finding was obtained by the skin sensitization test (Maximization method) using guinea pigs in accordance with the OECD Guidelines (Agricultural Chemical Registration Data, 1997). In addition, the skin sensitization test with 50% wettable powder by the Buehler method using guinea pigs showed negative (Agricultural Chemical Registration Data, 1997).
5 Germ cell mutagenicity Not classified - - - - The substance was regarded as outside the categories by the guidelines. Because the results of the chromosome aberration test using mouse spermatocytes, the micronucleus test in Chinese hamster bone-marrow cells (Agricultural Chemical Registration Data, 1981) and the in vivo micronucleus test using mouse bone-marrow cells (Agricultural Chemical Registration Data, 2005) are negative. And the in vitro mutagenicity test using bacteria (Agricultural Chemical Registration Data, 1981, 2005) is also negative.
6 Carcinogenicity Not classified - - - - Since it was classified into Group 3 according to IARC (IARC 73, 1999), it was set as the outside of Category. In addition, in pesticide registration trial in Japan, incidence of mammary gland tumors increased for females which received 70 - 1000ppm in the carcinogenicity tests using rat (Agricultural Chemical Registration Data, 1987). But in the test using rat which was performed in after years, generating of the tumor relevant to dose even at the dose of a maximum of 400ppm was not seen (Agricultural Chemical Registration Data, 1995). Moreover, in carcinogenicity tests using mice, generating of the tumor relevant to administration up to 3000ppm was not observed (Agricultural Chemical Registration Data, 1989). And as a result of estimation by the pesticide residues safety assessment committees, it is concluded that there is no fear of carcinogenicity to humans.
7 Reproductive toxicity Not classified - - - - Reproductive toxicity was not observed in the two-generation reproduction study using rats (Agricultural Chemical Registration Data , 1989). However, in the teratogenicity test, in the highest dose group where mild toxic effect was observed in the mother animals, the increase in the iincomplete ossification of embryo was observed (Agricultural Chemical Registration Data , 1989). Moreover, also in teratogenicity test on rabbits, in the highest dose group where mild toxic effect was observed in the mother animals, the increase of delayed ossification rate of embryo were observed (Agricultural Chemical Registration Data, 1987). Since these were slight influences, they were out of the Category according to the guideline. In addition, as a result of being evaluated in the Committee for Safety Evaluation of Residual Pesticides, it is concluded that there is no effect of reproductive toxicity in humans.
8 Specific target organ toxicity - Single exposure Not classified - - - - In oral study in rats, some symptoms such as hypoactivity, ataxia, emaciation, lacrimation, nasal discharges, polyuria, a ptosis, and salivation, are observed (Agricultural Chemical Registration Data 2002), and in inhalation exposure test symptoms such as hypoactivity, lacrimation, nasal discharges, polyuria, blepharoptosia, salivation, a bowing position, dyspnea, and less spontaneous activity, was observed in inhalation exposure studies (Agricultural Chemical Registration Data, 1991, 2002). But all applied dose were beyond the range of guidance value. Therefore, they were out of the Category.
9 Specific target organ toxicity - Repeated exposure Category 2 (heart, spleen) Warning H373: May cause damage to organs through prolonged or repeated exposure (heart, spleen) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In the subacute toxicity study (52-week dose) using dog, electrocardiographic abnormalities, atrium extension, and atrium line denaturation were observed at 1000 ppm (approximately 34mg/kg/day) (Agricultural Chemical Registration Data, 1991). This dose is guidance value within the Category 2. Moreover, in the subacute toxicity study (13-week treatment) using rat, the hemosiderin deposition of the spleen was observed at 500 ppm (equivalent: 34.0 mg/kg (male), 35.3 mg/kg (female)) (Agricultural Chemical Registration Data, 2005). This dose is also within the Category 2 in a guidance value, and it was classified into Category 2 (heart, spleen) based on the above results.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 72-hour EbC50=0.043mg/L of algae (Green algae) (Agricultural Chemical Registration Data, 2005).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity was Category 1, not rapidly degrading (BOD: 1% (existing chemical safety inspections data)), though supposed less bioaccumulative (log Kow=2.61 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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