GHS Classification Result

Chemical Name：epsilon-caprolactam
CAS：105-60-2

Result：
ID: 102
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data, though classified as "flammable" by ICSC (2004).
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 375degC (ICSC, 2004)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available - melting point: 70degC (ICSC, 2004), test temperature: 140degC
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (water solubility: 5.25kg/L (25degC), (HSDB (2006))
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 1,210mg/kg calculated from the testing data of rat LD50 (oral route) of 1,475mg/kg (SIDS (2003)), 1,876mg/kg (SIDS (2003)), 1,210mg/kg (MOE Risk Assessment vol. 2 (2003)).
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the testing data of rabbit LD50 (dermal route) of 1,438mg/kg (CERI Hazard Data 98-1 (1999)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - Based on the testing data of rat LC50 (4-hour inhalation) of 8.16mg/L (SIDS (2003)).
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on the description in the report on rabbit skin irritation tests (CERI Hazard Data 98-1 (1999)): the substance is considered to cause "mild irritation," although 4-hour application tests are not available.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the description in the report on rabbit eye irritation tests (CERI Hazard Data 98-1 (1999)): the substance is considered to cause "moderate irritation."
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - Based on the results of two guinea pigs skin sensitization tests - "not sensitizing" (SIDS (2003)).
5 Germ cell mutagenicity Not classified - - - - Based on the absence of data on germ cell multi-generation mutagenicity tests in vivo and germ cell mutagenicity tests in vivo, and negative data on somatic cell mutagenicity tests in vivo (chromosome aberration tests, micronucleus tests), described in IARC 71 (1999), SIDS (2003) DFGOT vol. 4 (1992) and NTP DB (Access on September 2005).
6 Carcinogenicity Not classified - - - - Due to the fact that the substance is classified as Category A5 by ACGIH (2003) and Group 4 by IARC (1999).
7 Reproductive toxicity Not classified - - - - Based on the description in SIDS (2003), ACGIH (7th, 2001) and IARC 71 (1999): Only nonspecific secondary effects, toxicologically insignificant effects or minimal effects are observed at dosing levels associated with general toxicity.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system, circulatory system), Category 3 (respiratory tract irritation, narcotic effects) Danger
Warning 		H370: Causes damage to organs (nervous system, circulatory system)
H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects)
H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on the human evidence including "oversensitiveness, somnolency, nasal hemorrhage, catarrh of the upper respiratory tract, dry nose and lips with cracks" (CERI Hazard Data 98-1 (1999), "disorder of the nervous and circulatory systems" (CERI Hazard Data 98-1 (1999)).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "an increase in bronchial response following nasal and upper respiratory irritation, respiratory disorder including impaired pulmonary function" (MOE Risk Assessment vol. 3 (2004)), and the evidence from animal studies including "labored respiration, nasal mucus, moist rale, moderate nasal turbinate respiratory mucosa hypertrophy and hyperplasia of the goblet cells in the nasal respiratory mucosa, deposition of eosinophilic substances in olfactory epithelial cells" (MOE Risk Assessment vol. 3 (2004)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - It was classified into Not classified from 96 hours LC50>100mg/L of the fish (Oryzias Latipest) (MOE eco-toxicity tests of chemicals (2001) and others.).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since it was not water-insolubility (the water-solubility =7.72*105mg/L (PHYSPROP Database, 2005)), and acute toxicity was low, it was classified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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