GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Cadmium
CAS：7440-43-9
Result：
| ID: | 101 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solids | Classification not possible | - | - | - | - | Although dust and granular cadmium are known to be combustible (cause dust explosion) (ICSC (J) (1993)), there is no data about other states. So it cannot be classified. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | Flash point: 250degC-570degC (>70degC) (ICSC (J), 1993; Hazardous Substance DB, 2nd, 1993) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | No data available |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Not cause a serious reaction with water. (Hazardous Substance DB, 2nd, 1993; ICSC(J), 1993) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Inorganic compounds containing no oxygen and halogen. |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Inorganic substance |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |
|
Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
Category 4 based on SPECIES: Rat; ENDPOINT: LD50;VALUE:1140 mg/kg; (PATTY (2001) |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Category 1 |
|
Danger | H330: Fatal if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Category 1 because of "SPECIES: Rat; ENDPOINT: LC50; VALUE: 0.0031 mg/L "(RTECS (2005) |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
| 5 | Germ cell mutagenicity | Category 2 |
|
Warning | H341: Suspected of causing genetic defects |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
The substance was classified as Category 2 by the technical guidelines. About half of the results of chromosome aberration tests using somatic cells from people who had epidemiological/occupational exposure are positive (IARC 58 (1993)). And based on EU-Annex1: Muta. Cat. 3 and the note in IARC 58 (1993): "the working group for carcinogenicity evaluation took into account the evidence that ionic cadmium shows genetic toxicity in various eukaryotic cells, including human cells." |
| 6 | Carcinogenicity | Category 1A |
|
Danger | H350: May cause cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
It was set as Category 1A based on the category of IARC: 1(1993). However, "as cadmium and its compound." |
| 7 | Reproductive toxicity | Category 2 |
|
Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
There is no description about the general toxicity to parent animals. However, decreases in the number of litter, foetal death, the growth inhibition and malformation of reduction of fetus were observed, and inhibitions of growth and motor activity development in newborn were also observed (IARC 58 (1993) and EHC 134 (1992)). Therefore, according to the technical guide, it was classified into Category 2. In addition, there are existing classifications, such as EU-Annex 1:Repr.Cat.3;R62-63. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (lung, respiratory system) |
|
Danger | H370: Causes damage to organs (lung, respiratory system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
The substance was classified as Category 1 (lung, respiratory organs). Based on the reports, such as "when humans are exposed to the fumes generated by heating, they may develop bronchitis, pneumonia, pulmonary edema, etc, and die in some cases" (ACGIH (2001)), and it "causes fatal pulmonary edema in animals after exposure by inhalation in high concentrations" (EHC (J) 134 (1997)). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (kidney, lung, blood, bone, respiratory system) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (kidney, lung, blood, bone, respiratory system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Chronic pneumonia, emphysema, proteinuria, etc. are observed in animal experiments (PATTY (5th, 2001)). "Long duration occupational exposure produces the serious chronic effects which is mainly concerned with lungs and kidney to humans. Moreover, the symptoms of osteoporosis or osteomalacia are affected. " (EHC(J) 134 (1997)), "Chronic exposures brings humans anemia, eosinophilia, rhinits, emphysema, and tooth decolorization, and renal disease". (ACGIH (7th, 2001)) "The primary target organ of chronic disorders is the kidney". (PATTY (5th, 2001)) They were classified into Category 1 (renal, lungs, blood, bones, respiratory systems) based on these descriptions. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | Insufficient data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 4 | - | - | H413: May cause long lasting harmful effects to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
Classified into Category 4, since it is a metal, behavior in water is unknown. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |