NITE - Chemical Management Field

GHS Classification Result

Chemical Name：1,2-Epoxypropane; Propylene oxide
CAS：75-56-9

Result：


ID:	99
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	Containing no chemical groups with explosive properties
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
5	Gases under pressure	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
6	Flammable liquids	Category 1		Danger	H224: Extremely flammable liquid and vapour	P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ...	The flash point is -37degC (c.c.) (ICSC, 1999) and the boiling point is 34degC, which is classified into Category 1. Classified into Class 3 and Packing Group I (UN#1280) (UN Recommendations on the Transport of Dangerous Goods)
7	Flammable solids	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
8	Self-reactive substances and mixtures	Not classified	-	-	-	-	No data available, though containing a distorted ring structure. Classified into Class 3 (UN#1280) by UN Recommendations on the Transport of Dangerous Goods.
9	Pyrophoric liquids	Not classified	-	-	-	-	Not pyrophoric when in contact with air at ordinary temperatures; the auto-ignition temperature is 449degC (ICSC, 1999)
10	Pyrophoric solids	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid substances are not available
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13	Oxidizing liquids	Not applicable	-	-	-	-	Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
14	Oxidizing solids	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no "-O-O-" structure
16	Corrosive to metals	Classification not possible	-	-	-	-	Test methods applicable to gaseous substances are not available - boiling point: 34degC (ICSC, 1999), test temperature: 55degC

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	Based on the testing data of rat LD50 (oral route) of 1,140mg/kg (EHC 56 (1985)), 520mg/kg (EHC 56 (1985)).
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Category 2		Danger	H330: Fatal if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the LC50 value (4 hours) of 399ppm, representing the lower of the two testing data of rat LC50 (4 hour inhalation of vapour) of 0.948mg/L (EHC 56 (1985)) and 4.1mg/L (EHC 56 (1985)), was lower than 90% of the saturated vapor concentration (580,000ppm) under a saturated vapour pressure of 59kPa (20degC) (ICSC (1999)), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available
2	Skin corrosion/irritation	Category 1		Danger	H314: Causes severe skin burns and eye damage	P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the description in the report on rabbit skin irritation tests (CERI-NITE Hazard Assessment No.47 (2004)): The substance is corrosive to the skin.
3	Serious eye damage/eye irritation	Category 1		Danger	H318: Causes serious eye damage	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician.	Based on the classification into Category 1 (Corrosive Substances).
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Category 1		Warning	H317: May cause an allergic skin reaction	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ...	Due to the fact that the substance is classified as Skin sensitization by ACGIH (2001).
5	Germ cell mutagenicity	Category 2		Warning	H341: Suspected of causing genetic defects	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Based on negative data on multi-generation mutagenicity tests (dominant lethal tests), the absence of data on germ cell mutagenicity in vivo, positive data on somatic cell mutagenicity tests in vivo (micronucleus tests and chromosome aberration tests), and the absence of data on germ cell genotoxicity tests in vivo, described in CERI-NITE Hazard Assessment No.47 (2004).
6	Carcinogenicity	Category 2		Warning	H351: Suspected of causing cancer	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Due to the fact that the substance is classified as Category R by NTP (2005), Group 2B by IARC (1994), Category A3 by ACGIH (2001) and Category B2 by EPA (1994).
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the description in the report on rat reproductive toxicity tests (CERI-NITE Hazard Assessment No.47 (2004)): Effects on female infertility are observed (though no description is available for general toxicity), while the number of corpora lutea decreases at dosing levels inducing general toxicity.
8	Specific target organ toxicity - Single exposure	Category 3 （Respiratory tract irritation）		Warning	H335: May cause respiratory irritation (respiratory tract irritation)	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the human evidence including "pulmonary/eye irritation, headache, hyposthenia, diarrhea, cyanosis" (CERI-NITE Hazard Assessment No.47 (2004)), and the evidence from animal studies including "dyspnea and nasal hemorrhage." Symptoms such as headache and hyposthenia are considered the secondary effects caused by cyanosis.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	Based on the fact that the results are derived solely from inhalation exposure tests, though dosing levels inducing general toxicity are "not classified."
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 3	-	-	H402: Harmful to aquatic life	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	It was classified into Category 3 from 96 hours LC50=52mg/L of the fish (Rainbow Trout) (EU-RAR (2002) and others.).
11	Hazardous to the aquatic environment （Long-term）	Not classified	-	-	-	-	Since there was rapidly degrading (the decomposition by BOD: 96% (Existing Chemical Safety Inspections Data)) and the bio-accumulation was low (log Kow=0.03 (PHYSPROP Database, 2005)), it was claasified into Not classified.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）