GHS Classification Result

Chemical Name：Ethylene glycol monomethyl ether
CAS：109-86-4

Result：
ID: 96
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no atom groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		The flashing point is 39degC (ICSC, 2003) (closed cup flash test), which is classified into Category 3, or Class 3 and Container III (UN Recommendations on the Transport of Dangerous Goods, UN#1188).
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Containing no atom groups with explosive or self-reactive properties
9 Pyrophoric liquids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the flashing point is 285degC (ICSC, 2003)
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Not classified - - - - Classified into Class 3 (UN Recommendations on the Transport of Dangerous Goods, UN#1188 )

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Based on the LD50 value of 2435mg/kg calculated from the testing data of rat LD50 (oral route) of 2460mg/kg (ECETOC TR64, 1995) , 3250mg/kg (ECETOC TR64, 1995) , 3400mg/kg (ECETOC TR64, 1995) and 2370mg/kg (MOE Risk Assessment Vol. 2, 2003).
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 1290mg/kg calculated from the testing data of rat LD50 (dermal route) of 1300 mg/kg (ECETOC TR64, 1995) , 2000mg/kg (DFGOT Vol.6, 1994) , 1290mg/kg (PATTY 4th, 2000) and 3900mg/kg (PATTY 4th, 2000) .
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the LC50 value of 6.18 mg/L (1,956ppm), calculated from the testing data of rat LC50 (7 hour inhalation of vapour) of 4.67mg/L (1,478ppm)(MOE Risk Assessment Vol. 2, 2003), was lower than 90% of the saturated vapor concentration (8,200 ppm) under a saturated vapour pressure of 0.83 kPa (20degC) (ICSC, 2003), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on the evidence of mild irritation from rabbit skin irritation tests (PATTY 4th, 2000), although insufficient data available.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Based on the evidence of mild irritation from rabbit skin irritation tests (PATTY 4th, 2000) and the human evidence of complete recovery within 48 hours (PATTY 4th, 2000), although insufficient data available.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Not classified - - - - Based on the negative data on heritable mutagenicity tests (dominant lethal tests) and somatic cell mutagenicity tests in vivo (chromosomal aberration tests) and the absence of data on germ cell mutagenicity tests in vivo, described in CERI Hazard Data 2000-26 (2001).
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence of effects on foetal development at dosing levels not toxic to dams in mice and rats, described in CERI Hazard Data 2000-26 (2001).
8 Specific target organ toxicity - Single exposure Category 1 (liver, kidney, central nervous system, testis) Danger H370: Causes damage to organs (liver, kidney, central nervous system, testis) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the human evidence including "acute hemorrhagic gastritis, fatty degeneration in the liver, black discoloration of the kidneys and renal tubule degeneration found at autopsy (EHC 115, 1990)"and "neurological symptoms (distraction, agitation, etc.), nausea, cyanosis, hyperventilation, tachycardia, metabolic acidosis and nephropathy" (EHC 115, 1990) and the evidence from animal studies including "degeneration of sperm cells and atrophy of testes observed in histological observation", "degeneration of germinal epithelium in the testes associated with cytoplasmic shrinkage and mitochondrial swelling in Sertoli cells" (ACGIH 7th, 2001). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. The gastric effect was probably due to irritation, and hyperventilation was not so severe as to be classified as Category 1, so the stomach and the respiratory system were not considered as target organs.
9 Specific target organ toxicity - Repeated exposure Category 1 (central nervous system, hematopoietic system, testis) Danger H372: Cause damage to organs through prolonged or repeated exposure (central nervous system, hematopoietic system, testis) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "anemia, central nervous system manifestation", "myelosuppression", "encephalopathy, bone-marrow damage, pancytopenia", "oligospermia, azoospermia"and "reduction of bone marrow cell density, degeneration of testis germinal epithelium, atrophy of thymic lymphatic tissue, decreased lymphocyte counts in the spleen and mesenteric lymphatic tissue" (ACGIH 7th, 2001) and the evidence from animal studies including "degeneration of testes" (IRIS, 2003). The effects on experimental animals were observede at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - It was classified into Not classified from 48 hours EC50>85mg/L of the crustacea (Daphnia magna) (MOE eco-toxicity tests of chemicals, 2002).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since it was not water-insolubility (the water-solubility =1.00*106mg/L (PHYSPROP Database, 2005)), and acute toxicity was low, it was classified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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