GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Ethylene glycol
CAS：107-21-1
Result：
| ID: | 94 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | Containing no chemical groups with explosive properties |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 6 | Flammable liquids | Not classified | - | - | - | - | The flash point is 111degC (c.c.) (ICSC, 2000) |
| 7 | Flammable solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Containing no chemical groups with explosive or self-reactive properties |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 398degC (ICSC, 2000) |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements) |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 5 | - | Warning | H303: May be harmful if swallowed | P312: Call a POISON CENTER or doctor/physician if you feel unwell. | Based on the rat LD50 (oral route) of 4,000-10,200mg/kg (CICAD 45 (2002)). |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | - | Based on the rat LD50 (dermal route) of 10,600 mg/kg (CICAD 45 (2002)). |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | Insufficient data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Category 3 | - | Warning | H316: Causes mild skin irritation | P332+P313: If skin irritation occurs: Get medical advice/attention. | Based on the description in the report on rabbit and guinea pig skin irritation tests (CICAD 45 (2002)): "mild dermal irritation in rabbits and guinea pigs." |
| 3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
Based on the description in the report on rabbit eye irritation tests (CICAD 45 (2002)): Short-term exposure to ethylene glycol (liquid or vapour) causes conjunctival irritation with no permanent damage to the cornea. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | Insufficient data available |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | Based on the negative data on rat dominant lethal tests, absence of data on germ cell mutagenicity tests in vivo, and the negative data on somatic cell mutagenicity tests in vivo (chromosome aberration tests/micronucleus tests), described in CICAD 45 (2002). |
| 6 | Carcinogenicity | Not classified | - | - | - | - | Due to the fact that the substance is classified as Category A4 by ACGIH (2001). |
| 7 | Reproductive toxicity | Category 1B |
|
Danger | H360: May damage fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the description in the report on mouse continuous breeding and rat teratogenicity tetss (CICAD 45 (2002)): Malformations, retarded ossification and unossification are observed in offspring at dosing levels not toxic to dams. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system, kidney, heart, respiratory system) |
|
Danger | H370: Causes damage to organs (central nervous system, kidney, heart, respiratory system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the human evidence including: "consciousness disorder, convulsions and stupor (after 34 days of accidental ingestion); an increase in urea nitrogen, creatinine and uric acid concentrations (blood examination); albuminuria, hematuria and nephropathy (urine examination); degeneration of convoluted tubules (renal biopsy); mild pulmonary congestion," "acute effects are observed in four stages: effects on the central nervous system (after 0.5-12 hours of exposure); effects on the heart-lung system (after 12-36 hours of exposure); nephropathy in specimens surviving from Stage 1 and 2 (exposure to ethylene glycol); degeneration of the central nervous system" (CERI Hazard Data 97-24 (1998)). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (central nervous system, respiratory system, heart) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (central nervous system, respiratory system, heart) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on human evidence including "loss of consciousness and nystagmus," "mild headache and backache, upper respiratory tract irritation" (MOE Risk Assessment vol. 3 (2004)), and the evidence from animal studies including "inflammatory degeneration of the lung and heart" (MOE Risk Assessment vol. 3 (2004) The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Not classified | - | - | - | - | It was classified into Not classified from 96 hours LC50>100mg/L of the fish (Oryzias Latipest) (MOE eco-toxicity tests of chemicals (2001) and others.). |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - | - | Since it was not water-insolubility (the water-solubility =1.00*106mg/L (PHYSPROP Database, 2005)), and acute toxicity was low, it was classified into Not classified. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |