Chemical Name:Isoprene
CAS:78-79-5
ID: | 90 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | Containing no chemical groups with explosive properties |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
6 | Flammable liquids | Category 1 | Danger | H224: Extremely flammable liquid and vapour |
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
The flash point is -54degC (c.c.) (ICSC, 2004) and the boiling point is 34degC, which is classified into Category 1. Those containing stabilizers are classified into Class 3 and Packing Group I (UN#1218) (UN Recommendations on the Transport of Dangerous Goods) | |
7 | Flammable solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | - | Classification not possible due to lack of data, though containing unsaturated bonds. Those containing stabilizers are classified into Class 3 (UN Recommendations on the Transport of Dangerous Goods, UN#1218) |
9 | Pyrophoric liquids | Not classified | - | - | - | - | Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 220degC (ICSC, 2004) |
10 | Pyrophoric solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing no oxygen, fluorine and chlorine |
14 | Oxidizing solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to gaseous substances are not available - boiling point: 34degC (ICSC, 2004), test temperature: 55degC |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 5 | - | Warning | H303: May be harmful if swallowed | P312: Call a POISON CENTER or doctor/physician if you feel unwell. | Based on the testing data of rat LD50 (oral route) of 2,043mg/kg (CERI-NITE Hazard Assessment No.45 (2005)). |
1 | Acute toxicity (Dermal) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected. |
1 | Acute toxicity (Inhalation: Vapours) | Not classified | - | - | - | - | Based on the rat LC50 (4 hour inhalation of vapour) value of 63,600ppm (180mg/L) (CERI-NITE Hazard Assessment No.45 (2005) was lower than 90% of the saturated vapour concentration (530,000ppm) under a saturated vapour pressure of 53.2kPa (20degC) (ICSC, 2004), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | No data available |
2 | Skin corrosion/irritation | Category 3 | - | Warning | H316: Causes mild skin irritation | P332+P313: If skin irritation occurs: Get medical advice/attention. | Based on the evidence of "mild irritation" from tests on human volunteers (CERI-NITE Hazard Assessment No.45 (2005)). |
3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
Based on the evidence of "mild irritation" from tests on human volunteers (CERI-NITE Hazard Assessment No.45 (2005)). |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
5 | Germ cell mutagenicity | Category 2 | Warning | H341: Suspected of causing genetic defects |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the absence of data on multi-generation mutagenicity tests and germ cell mutagenicity tests in vivo, positive data on somatic cell mutagenicity tests in vivo (micronucleus tests) and the absence of data on germ cell genotoxicity tests in vivo, described in CERI-NITE Hazard Assessment No.45 (2005). | |
6 | Carcinogenicity | Category 2 | Warning | H351: Suspected of causing cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Due to the fact that the substance is classified as Category R by NTP (2005) and Group 2B by IARC (1999). | |
7 | Reproductive toxicity | Classification not possible | - | - | - | - | Because of the absence of data on reproductive toxicity; the results of rat developmental toxicity tests (CERI-NITE Hazard Assessment No.45 (2005)) suggest a very low or negligible effect on the embryo (body weight reduction, delayed ossification, etc.). |
8 | Specific target organ toxicity - Single exposure | Category 3 (Narcotic effects, Respiratory tract irritation) | Warning |
H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation) H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation) |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the human evidence including "adverse effects on the central nervous system, dyspnea, lowering of consciousness, burning sensation, cough, dizziness, smothering feeling, nausea, breathlessness, pharyngalgia" (MOE Risk Assessment vol. 1 (2002)). Respiratory irritation, suppression of the central nervous system and narcotic effects are observed. | |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory system, nervous system), Category 2 (liver, blood system) |
Danger Warning |
H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, nervous system) H373: May cause damage to organs through prolonged or repeated exposure (liver, blood system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on human evidence including "catarrhal inflammation, atrophic degeneration of the upper respiratory tract, a reduced sense of smell, delay in the reflex latency, a decrease in blood pressure" (CERI Hazard Data 97-5 (2002)), and the evidence from animal studies including "hepatocellular vacuolar degeneration, a decrease in red blood cell count, low hemoglobin concentrations," "macrocytic anemia," "spinal degeneration" (CERI-NITE Hazard Assessment No.45 (2005)). The effects on "nervous systems" and "liver and blood systems" are observed at dosing levels within the guidance value ranges for Category 1 and Category 2, respectively. | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 2 | - | - | H401: Toxic to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It was classified into Category 2 from 48 hours EC50=3.2mg/L of the crustacea (Daphnia magna) (MOE eco-toxicity tests of chemicals, 2000). |
11 | Hazardous to the aquatic environment (Long-term) | Category 2 | - | H411: Toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Although acute toxicity was Category 2 and the bio-accumulation potential was low (BCF=20(Existing Chemical Safety Inspections Data)), since there was no rapidly degrading (the decomposition by BOD: 2%(Existing Chemical Safety Inspections Data)), it was classified into Category 2. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |