GHS Classification Result

Chemical Name：Amitrol
CAS：61-82-5

Result：
ID: 85
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-flammable (IUCLID (2000))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-flammable (IUCLID, 2000)
11 Self-heating substances and mixtures Not classified - - - - Non-flammable (IUCLID, 2000)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Containing no oxygen , chlorine and fluorine.
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on rat LD=25000 mg/kg (ACGIH (2001)) and 24600 mg/kg (EHC 158 (1994)), it was set as the outside of Category.
1 Acute toxicity （Dermal） Not classified - - - - Based on rabbit LD50 >10000mg/kg (EHC 158 (1994)), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. There are descriptions "although slight erythema was observed only with higher doses, recovered in 48 hours" and "a very slight stimulativeness was found" as results of two skin irritation study on rabbits (EHC 158 (1994), ACGIH (2001)). Moreover, as for humans, mild irritations in occupational exposure and slight dermatitis on three persons among six in 24-hour apply patch tests are reported (EHC 158 (1994)). Since very slight stimulativeness was reported both on humans and animals as mentioned above, it was classified as out of Category 3.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		It is estimated mild stimulativeness by the eye irritation test using a rabbit (EHC 158 (1994), IUCLID (2000)). There is also description (EHC 158 (1994)) that most animals were recovered within 24 hours, and it was set as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Although skin sensitization is not found by the two tests using guinea pigs: Open epicutaneous test and Buehler test (DFGOT vol.18 (2002)), we classified this as Category 1 based on IUCLID (2000), which obtains a positive finding in the Magnusson-Kligman maximization test (EHC 158 (1994)) and reports a case that reveals allergic dermatitis in human patch test (EHC 158 (1994)).
5 Germ cell mutagenicity Not classified - - - - There is the results of the 2 dominant lethal tests using mice (multi-generation mutagenicity tests) are both negative (EHC 158(1994)), and the results of the 3 micronucleus tests using mouse bone-marrow cells (the somatic in vivo mutagenicity tests) are all negative (IARC 79(2001), EHC 158(1994)). So the substance was regarded as outside the categories.
6 Carcinogenicity Not classified - - - - It was estimated by two or more organizations and Category differed. But based on the classification (2001) of group 3 by the latest IARC, it was set as the outside of Category. In addition, as information about the carcinogenicity of humans and animals, there is also a report that tumor generating of the thyroid gland, liver, and hypophysis increased in studies using rats (DFGOT vol.4 (1992), IARC 41 (1986)).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		To a rat, increase of child mortality rate after weaning in one-generation exposure (DFGOT vol.18 (2002)), change of indices of copulation or reproduction in two-generation exposure (JMPR 926 (1997)), to mouse increase of resorpted embryo in exposure during organogenetic period (DFGOT vol.18 (2002)) and increase of fetal death (JMPR 926(1997)), and to rabbit increase of miscarriage and morphological change as fetal anophthalmia or microphthalmia (JMPR 926(1997)) are observed. Since there is general toxicity such as reduced weight gain and changing of organ weigt even in parent animals in these dose, it is considered as in the Category 2.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No symptoms have been observed after inhalation exposure to the substance in rats (ACGIH (2001)), but effects on the lungs and nervous system after exposure through oral intake or inhalation of mixture containing the substance in humans have been reported (EHC 158 (1994, IARC 79 (2001)). Although it is suggested that thiocyanate which is mixed in the substance is the leading cause (IARC 79(2001)), the possibility of the substance itself being the cause could not be ruled out. So it was decided that the substance could not be classified due to insufficient data. (EHC 158 (1994), IARC 79 (2001)).
9 Specific target organ toxicity - Repeated exposure Category 1 (thyroid), Category 2 (liver) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (thyroid)
H373: May cause damage to organs through prolonged or repeated exposure (liver) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In the repeated oral administration test using rat, at 0.5-15 mg/kg (number of days of exposure is 90 daysin equivalent) dose, there are some reports of the hypertrophy of thyroid, thyroid hyperplasia and goiter (EHC 158 (1994), IARC 79 (2001), DFGOT vol.18 (2002), JMPR 280 (1974)). Moreover, at 35 mg/kg (number of days of exposure is 90 days in equivalent), vacuolation of hepatocyte and fatty degenerations are observed (EHC 158 (1994)). Based on these results, they were classified into as Category 1 (thyroid) and Category 2 (liver) with reference to the guidance value.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 48-hour EC50=1.54mg/L of Crustacea (Daphnia magna) (EHC158, 1994).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 2, since acute toxicity was Category 2 and not rapidly degrading (BOD: 0% (existing chemical safety inspections data)), though less bio-accumulative (BCF<=3.1 (existing chemical safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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