GHS Classification Result

Chemical Name：Aniline, 2-methoxy-
CAS：90-04-0

Result：
ID: 83
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Flash point: 98degC (Hommel, 1991) Boiling point: 225degC (Merck, 13th, 2001)
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 415degC(ICSC (1999))
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG No. 2431, Class: 6.1, PG III

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		SPECIES: Rat ENDPOINT: LD50 VALUE: 2000 mg/kg REFERENCE SOURCE: PATTY (5th, 2001)
1 Acute toxicity （Dermal） Not classified - - - - Based on not having observed fatal cases in 2000mg/kg in a rat (EU-RAR (2002)), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - As aerosol, it is rat LC50 >3.87mg/L (EU-RAR (2002)). Since Category could not be specificked, it presupposed it cannot classify.
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Erythema and slight edemas were observed in the skin irritation test on rabbits based on the OECD guideline 404. But all were described to have disappeared within 72 hours after patch removal (EU-RAR (2002)). Therefore it was classified as Category 3.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Although dropsy and redness of a conjunctiva, iritis, and keratitis were observed in the eye stimulativeness examination of the rabbit based on the OECD guideline 404, all were disappear within seven days after apply (EU-RAR (2002)). So it was set to Category 2B.
4 Respiratory sensitization Classification not possible - - - - Skin sensitization test using guinea pigs assesses this as "a weak sensitization" (EU-RAR (2002) and there is a report that the frequency of atopic dermatitis became high among children who are exposed to a mixture including this product in humans (EU-RAR (2002)). However, it appends a note that adequacy is lacking in the former (guinea pigs) because of insufficient information, and it describes that it is difficult to evaluate whether this product is a cause beause the exposing mixture includes 20 or more substances in the latter (humans). Therefore, we classified this as "uncategorizable" because of insufficient data.
4 Skin sensitization Classification not possible - - - - Skin sensitization test using guinea pigs assesses this as "a weak sensitization" (EU-RAR (2002) and there is a report that the frequency of atopic dermatitis became high among children who are exposed to a mixture including this product in humans (EU-RAR (2002)). However, it appends a note that adequacy is lacking in the former (guinea pigs) because of insufficient information, and it describes that it is difficult to evaluate whether this product is a cause beause the exposing mixture includes 20 or more substances in the latter (humans). Therefore, we classified this as "uncategorizable" because of insufficient data.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		All the results of the micronucleus tests in rats and mice, which were done as in vivo mutagenicity tests using somatic cells, are negative (DFGOT vol.10(1998)). But induction was observed in the gene mutation test using transgenic mice (EU-RAR (2002)). So the substance was classified as Category 2 by the guidelines. There are also positive results from some in vivo DNA synthesis tests or DNA adduct tests and host mediated assays (DFGOT vol.10 (1998)).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It is classified into 2B in IARC and into A3 in ACGIH at almost same period. A GHS classifications is set as Category 2 even if either was adopted.
7 Reproductive toxicity Classification not possible - - - - Classification not possible due to lack of data
8 Specific target organ toxicity - Single exposure Category 2 (central nervous system, blood) Warning H371: May cause damage to organs (central nervous system, blood) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		After more than 690mg/kg of the substance was orally administered to rats, vascular stasis and increase in methaemoglobin level as well as central symptoms, such as curling up, staggering, decrease in locomotor activity, vertigo (DFGOT vol.10 (1998), EU-RAR (2002)), cyanosis (EU-RAR (2002)) were observed. Central symptoms were slightly observed after the exposure to 3.87mg/L by inhalation (DFGOT vol.10 (1998)). The substance was classified as Category 2 (central nervous system, blood) based on these results.
9 Specific target organ toxicity - Repeated exposure Category 2 (blood) Warning H373: May cause damage to organs through prolonged or repeated exposure (blood) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Due to the description that in the four-week repeated oral administration study using rat, the hemalytic anemia was occurred in more than 80 mg/kg dose (EU-RAR (2002), DFGOT vol.10 (1998)), it was classified into Category 2 (blood). In addition, in human, although anemia did not appear in the workers who were exposed for six months in ortho anisidine (0.4 ml/m3) day for 3.5 hours per day, the increase of sulfhemoglobin and methemoglobin are observed (DFGOT vol.10(1998)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 48-hour EC50=6800microg/L of Crustacea (Daphnia magna), and others (MOE Risk Assessment No.2, 2003).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since rapidly degrading (the decomposition of TOC: 83% (Existing Chemicals Safety Check Data)), and supposed less bio-accumulative (log Kow=1.18 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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