GHS Classification Result

Chemical Name:Acetaldehyde
CAS:75-07-0

Result:
ID: 82
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Category 1 Danger H224: Extremely flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
The flash point is -38degC (c.c.) (ICSC, 2004) and the boiling point is 20.2degC, which is classified into Category 1. Classified into Class 3 and Packing Group I (UN#1089) (UN Recommendations on the Transport of Dangerous Goods)
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 185degC (ICSC, 2004)
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Not classified - - - - Classified into Class 3 (UN Recommendations on the Transport of Dangerous Goods, UN#1089)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on the testing data of rat LD50 (oral route) of 660mg/kg (EHC 167 (1995)).
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Not classified - - - - Based on the rat LC50 (4 hour inhalation of vapour) value of 24 mg/L (13,000 ppm) (EHC 167, 1995) was lower than 90% of the saturated vapor concentration (993,000 ppm) under a saturated vapour pressure of 100.6 kPa (20degC) (IUCLID, 2000), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
Based on the description in the report on the rabbit skin irritation test (ACGIH (7th 2001)): "moderate irritant".
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
Based on the results of rabbit eye irritation tests (ACGIH 7th (2001)): Extremely irritating but no irreversible effects observed.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - Insufficient data available
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the absence of data on germ cell multi-generation mutagenicity tests in vivo, negative data on germ cell mutagenicity tests in vivo (micronucleus tests in the spermatocytes of mice), positive data on somatic cell mutagenicity tests in vivo (micronucleus and chromosome aberration tests), and absence of data on germ cell genotoxicity tests in vivo, described in CERI-NITE Hazard Assessment No.61 (2004)
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Due to the fact that the substance is classified as Category R by NTP (2005), Group 2B by IARC (1999), and Category B2 by IRIS (2005).
7 Reproductive toxicity Classification not possible - - - - Insufficient data available. The results of intraperitoneal administration to female CF rats (single exposure on the 10th, 11th and 12th days of pregnancy, or multiple exposure to 0, 50, 75 and 100 mg/kg on the 10th, 11th and 12th days of pregnancy, respectively) suggest absorbed embryo and malformation (edema, symphysodactylia, microcephalia, micrognathia, exencephalia, hydrocephalus, growth retardation, cataract, body/placenta weight reduction) at dose levels of 50 mg/kg or more (no adverse effects are observed in parent animals at all the dose levels), described in CERI-NITE Hazard Assessment No.61 (2004). Likewise, the results of oral administration to female SD rats (multiple exposure to 200mg/kg (3% solution) on the 6th-18th days of pregnancy) suggest adverse effects on the formation of the fetal skeleton (No details and data on the impact on parent animals are available). However, the former are based on intraperitoneal administration and the latter provide no description of the impact on parent animals, etc. - both of which are not worth being taken into account.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system, nervous system), Category 3 (narcotic effects) Danger
Warning
H370: Causes damage to organs (respiratory system, nervous system)
H336: May cause drowsiness or dizziness (narcotic effects)
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
Based on human evidence including "cough, a burning pain in the nose, throat and eye," "headache, coma, irritation to the eye, skin, respiratory organs and throat, bronchitis, pulmonary edema, motor paralysis, decease" (CERI-NITE Hazard Assessment No.61 (2004)), "general narcotic effects, clouding of consciousness, bronchitis, pulmonary edema" (MOE Risk Assessment vol. 1 (2002)).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system, nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the human evidence including "erythema, cough, pulmonary edema, narcotic effects" (ACGIH 7th (2001)), "headache, narcotic effects, paralysis, a decrease in respiration rate, irritation to the respiratory organs, bronchitis, pulmonary edema" (CaPSAR (2000)).
10 Aspiration hazard Classification not possible - - - - Although kinematic viscosity stands at 0.314mm2/S (1degC), the kinematic viscosity is non-existent at 40degC, with the boiling point being 20.2degC (ICSC (2004)).

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 2 from 96 hours LC50=2.1mg/L of the fish (Bluegill) (CERI/NITE Hazard Assessment Report, 2004).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since there was rapidly degrading (the decomposition by BOD: 80% (Existing Chemical Safety Inspections Data)) and the bio-accumulation was low (log Kow=-0.34 (PHYSPROP Database, 2005)), it was claasified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

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Model SDS by MHLW

MHLW Website (in Japanese Only)


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