GHS Classification Result

Chemical Name：1,1-Dimethylhydrazine
CAS：57-14-7

Result：
ID: 79
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Classification not possible, because of lack of data (though the substance is hydrazines, containing chemical groups associated with explosive properties). Classified into Class 3, Division 6.1 and Class 8 (UN#1163) (UN Recommendations on the Transport of Dangerous Goods)
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		The flash point is -15degC (c.c.) (ICSC (2004)), and the boiling point is 63degC, which is classified as Category 2. Classified into Class 3, Division 6.1 and Class 8 (UN#1163) (UN Recommendations on the Transport of Dangerous Goods)
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not classified - - - - No data available, though the substance is hydrazines, containing chemical groups associated with explosive properties. Classified into Class 3, Division 6.1 and Class 8 (UN#1163) (UN Recommendations on the Transport of Dangerous Goods)
9 Pyrophoric liquids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 249degC (ICSC,2004)
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Cannot be classified due to lack of data. Classified into "Class 8: corrosive substances" by the UN Recommendations on the Transport of Dangerous Goods. However, the category includes skin corrosivity, and it is unclear whether the substance is classified as "metal" corrosive (UN#1163).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 131mg/kg calculated from the testing data of rat LD50 (oral route) of 122mg/kg, 250mg/kg and 360mg/kg (PATTY (4th, 2000)).
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the rabbit LD50 (dermal route) value of 1,060mg/kg (PATTY (4th, 2000)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LC50 value of 252ppm, representing the lower of the two testing data of rat LC50 (4-hour inhalation exposure) of 252ppm (equivalent to 0.66mg/L) and LC50 (1hour) of 1,411ppm (equivalent to 3.67mg/L; 708ppm for 4 hours (equivalent to 1.84mg/L)) (PATTY (4th, 2000)) was lower than 90% of the saturated vapour concentration (207,000ppm) under a saturated vapour pressure of 156.8torr (25degC), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values of gas.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - PATTY (4th, 2000) describes findings from skin irritation tests in rabbits and guinea pigs: "Application of small doses produced slight erythema." However, the study details (application doses, concentrations, etc.) are not available. Also, the substance is reported to be strong alkaline (PATTY (4th, 2000)) but the pH is not shown. Given these uncertainties, it was decided not to use this specific observation for classification.
3 Serious eye damage/eye irritation Classification not possible - - - - PATTY (4th, 2000) describes findings from rabbit eye irritation tests: "The substance induced mild conjunctivitis and slight erythema, with effects resolving within 5 days." Also, eye irritation studies in rodents provide no evidence of "irreversible eye damage." However, the study details (application doses, concentrations, etc.) are not available. Moreover, the substance is reported to be strong alkaline (PATTY (4th, 2000)) but the pH is not shown. Given these uncertainties, it is decided not use these observations for classification.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Category 1B Danger H340: May cause genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on negative data on multi-generation mutagenicity tests (dominant lethal tests) and positive data on germ cell mutagenicity tests in vivo (micronucleus tests on mouse sperm cells), described in IARC 71 (1999).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Due to the fact that the substance is classified as Category R by NTP (2005), Category A3 by ACGIH (2001) and Group 2B by IARC (1999).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence of pup development at doses causing maternal toxicity, described in IARC 71 (1999), ACGIH (7th, 2001) and PATTY (4th, 2000).
8 Specific target organ toxicity - Single exposure Category 1 (nervous system, respiratory system) Danger H370: Causes damage to organs (nervous system, respiratory system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the human evidence including "effects on respiratory organs, nausea, vomiting, neurological effects and pulmonary edema" (PATTY (4th, 2000)).
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, nervous system, blood system, kidney) Danger H372: Cause damage to organs through prolonged or repeated exposure (liver, nervous system, blood system, kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "fatty liver" (IARC 4 (1974)), and the evidence from animal studies including "tremor, dyspnea, lethargy, spasm, lethargy, salivation, diarrhea, ataxia, hematological effects, renal tubular damage" (PATTY (4th, 2000)), "neurological symptoms, body weight reduction, hemolytic anemia and hemosiderin deposition in the reticuloendothelial system" (ACGIH (7th, 2001)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 96 hours LC50=7.85*103microg/L of the fish (Fathead Minnows) (AQUIRE, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Although acute toxicity was Category 2 and the bio-accumulation potential was low (log Kow=-0.4(Existing Chemical Safety Inspections Data)), since there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information