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GHS Classification Result

Chemical Name：monocrotophos
CAS：6923-22-4

Result：


ID:	77
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	-	-	-	-	Solid (GHS definition)
7	Flammable solids	Classification not possible	-	-	-	-	No data available by regulated examination methods, though "Flammable under specific conditions" (ICSC (J) (1995))
8	Self-reactive substances and mixtures	Classification not possible	-	-	-	-	No data available
9	Pyrophoric liquids	Not applicable	-	-	-	-	Solid (GHS definition)
10	Pyrophoric solids	Classification not possible	-	-	-	-	No data available
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid or solid substances at 140degC are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Classification not possible	-	-	-	-	No data available
13	Oxidizing liquids	Not applicable	-	-	-	-	Solid (GHS definition)
14	Oxidizing solids	Classification not possible	-	-	-	-	No data available
15	Organic peroxides	Not applicable	-	-	-	-	Containing no -0-0- structure
16	Corrosive to metals	Classification not possible	-	-	-	-	Although there is information that it corrodes various metals (HSDB (Access on Jan. 2006)), there is no data based on set test methods.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 2		Danger	H300: Fatal if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	SPECIES: Rat ENDPOINT: LD50 VALUE: 17 mg/kg, 14mg/kg REFERENCE SOURCE: ACGIH (2002)
1	Acute toxicity （Dermal）	Category 2		Danger	H310: Fatal in contact with skin	P302+P350: IF ON SKIN: Gently wash with plenty of soap and water. P262: Do not get in eyes, on skin, or on clothing. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	Based on rat LD50 value: 112mg/kg (ACGIH, 2002), rabbit LD50 value: 354mg/kg and 270mg/kg (ACGIH, 2002), the lowest value of rat LD50 was adopted and it was set as Category 2.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Category 1		Danger	H330: Fatal if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Calculated based on rat LC50 (4 hours) value: 0.063mg/L and 0.1mg/L (ACGIH, 2002), and LC50 (1 hour) value:0.163mg/L (4-hour equivalent 0.0408mg/L) (ACGIH, 2002). The calculation value was lower than these lowest value. And 0.0408 mg/L of lowest value was adopted and set it to category 1.
2	Skin corrosion/irritation	Not classified	-	-	-	-	Since ACGIH (2002) describes that no skin irritation was observed in the test on rabbits, it was classified as out of Category.
3	Serious eye damage/eye irritation	Not classified	-	-	-	-	From description that there was no eye irritation in the test using the rabbit of ACGIH (2002), it was set as the outside of Category.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data
4	Skin sensitization	Not classified	-	-	-	-	Classified as out of category because ACGIH (2002) describes that the standard test using guinea pigs found no sensitization.
5	Germ cell mutagenicity	Category 2		Warning	H341: Suspected of causing genetic defects	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Although there is a positive result from the chromosome aberration test using rat bone-marrow cells, which is an in vivo mutagenicity test using somatic cells (ACGIH, 2002), there is no positive result from in vivo genotoxicity tests using germ cells. So the substance was classified as Category 2.
6	Carcinogenicity	Not classified	-	-	-	-	Not classified because of "A4"(ACGIH, 2002)
7	Reproductive toxicity	Not classified	-	-	-	-	According to ACGIH (2002), there was no obvious reproductive toxicity in the dose causing general toxicity to parent animals in the pregnancy peroral administration using rat and rabbit, and in the two generation reproduction study using rat. So it was considered as on the outside of Categry.
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)		Danger	H370: Causes damage to organs (nervous system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	The substance was classified as Category 1 (nervous system). Based on the reports of observed symptoms indicating the effects on the nervous system in human exposure cases, and on observed symptoms indicating the effects on the nervous system in inhalation exposure tests using rats and oral administration tests using rats and mice, at dosages within the guidance values for Category 1.
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (nervous system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	It was classified into Category 1 (nerve systems) from description that the decreased brain cholinesterase activities was observed with the given dose within the guidance value range of Category 1 in the oral study using the rat, mouse, or dog of ACGIH (2002).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 96-hour LC50=160microg/L of Crustacea (Amphipod) (AQUIRE, 2003).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=-0.2(PHYSPROP Database, 2005)).

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model SDS by MHLW	MHLW Website （in Japanese Only）