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GHS Classification Result

Chemical Name：2-butylphenyl methylcarbamate
CAS：3766-81-2

Result：


ID:	74
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	-	-	-	-	Solid (GHS definition)
7	Flammable solids	Classification not possible	-	-	-	-	No data available
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9	Pyrophoric liquids	Not applicable	-	-	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	-	-	-	-	The flash point is 142 degC (Agricultural Chemical Registration Data (1995)), and even if it contacts air at room temperature, it does not ignite.
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid or solid substances at 140degC are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	-	-	-	-	Solid (GHS definition)
14	Oxidizing solids	Not applicable	-	-	-	-	Organic compounds containing oxygen, chlorine and fluorine, and these elements are chemically bonded only to carbon (but not to other elements).
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no -0-0- structure
16	Corrosive to metals	Classification not possible	-	-	-	-	No data available

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	SPECIES: Rat (female) ENDPOINT: LD50 VALUE: 425 mg/kg REFERENCE SOURCE: Agricultural Chemicals abstracts
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on rat LD50 value: >5000mg/kg (Agricultural Chemicals abstracts), it was set as the outside of Category.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	Rat LC50 (4 hours) value: >2.50mg/L, and one female died from 1.92mg/L and three females died from 2.50mg/L (Agricultural-Chemicals abstracts). But the category could not be specified only by these data and it cannot be classified since data is insufficient.
2	Skin corrosion/irritation	Not classified	-	-	-	-	Since skin changes that matches criteria of mild irritation were not observed in the skin irritation test on rabbits (Agricultural-Chemicals abstracts), it was classified as out of Category.
3	Serious eye damage/eye irritation	Not classified	-	-	-	-	Since change of the eye which is adapted for criteria for diagnosis of irritation was not admitted as a result of the eye stimulativeness examination using a rabbit (Agricultural-Chemicals abstracts), it was set as the outside of Category.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data
4	Skin sensitization	Not classified	-	-	-	-	Classified as out of category because the result of a sensitization test using guinea pigs found no sensitization (agrochemical abstract).
5	Germ cell mutagenicity	Not classified	-	-	-	-	Because there is a negative result in a micronucleus test using mouse bone-marrow, which is an in vivo mutagenicity test using somatic cells (Agricultural-Chemicals abstracts), the substance was regarded as outside the categories.
6	Carcinogenicity	Not classified	-	-	-	-	Neither of the organizations had divided about carcinogenic. But carcinogenic was not observed as a result of the carcinogenic test using rats and mice (Agricultural-Chemicals abstracts). So it was set as the outside of Category.
7	Reproductive toxicity	Not classified	-	-	-	-	Since reproductive toxicity and teratogenicity are not observed in rat and rabbit teratogenic test with dose occuring general toxicity (Agricultural-Chemicals abstracts), they were considered as on the outside of Categry. Moreover, there was no reproductive toxicity in rat reproductive test in spite of the dose not occuring have general toxicity to parent animals (Agricultural-Chemicals abstracts).
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)		Danger	H370: Causes damage to organs (nervous system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Clonic convulsions were observed at the dosage within the guidance values for Category 1 in an oral administration test using rats (Agricultural Chemical Abstracts), so it was judged that the target organ was the nervous system. So the substance was classified as Category 1 (nervous system).
9	Specific target organ toxicity - Repeated exposure	Not classified	-	-	-	-	Since the serious toxic effect by the dose over the guidance value range of Category 2 in the oral study using rat was not observed (Agricultural Chemicals abstracts), it was classified into the outside of Category.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 48-hour EC50=0.0103mg/L of Crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2004).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1, since acute toxicity was Category 1, not rapidly degrading (BOD: 0% (existing chemical safety inspections data)), though less bioaccumulative (BCF=4 (existing chemical safety inspections data)).

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model SDS by MHLW	MHLW Website （in Japanese Only）