Chemical Name:Hexamethylene diisocyanate
CAS:822-06-0
ID: | 66 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | Containing no chemical groups with explosive properties |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
6 | Flammable liquids | Not classified | - | - | - | - | The flash point is 140degC (open cup flash test) (ICSC (2004)) |
7 | Flammable solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Containing no chemical groups with explosive or self-reactive properties |
9 | Pyrophoric liquids | Not classified | - | - | - | - | Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 454degC (ICSC,2004) |
10 | Pyrophoric solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements) |
14 | Oxidizing solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
16 | Corrosive to metals | Not classified | - | - | - | - | Classified into Division 6.1 (UN#2281) (UN Recommendations on the Transport of Dangerous Goods) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 | Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
Based on the LD50 value of 747mg/kg calculated from the testing data of rat LD50 (oral route) of 738mg/kg, 960mg/kg (CERI Hazard Data 2000-50 (2001)), 746mg/kg, 959mg/kg (SIDS (2004)). | |
1 | Acute toxicity (Dermal) | Category 3 | Danger | H311: Toxic in contact with skin |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment (see ... on this label). P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the rabbit LD50 (dermal route) value of 593mg/kg (CERI Hazard Data 2000-50 (2001)) representing the lower of the two testing data, 593mg/kg and 599mg/kg (SIDS (2004)). | |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected. |
1 | Acute toxicity (Inhalation: Vapours) | Category 1 | Danger | H330: Fatal if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent (see ... on this label). P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the rat LC50 (4 hours) value of 20ppm, calculated from the testing data of rat LC50 (inhalation of vapour) of 0.31mg/L (ATSDR (1998)), 0.06mg/L (MOE Risk Assessment vol. 2 (2003)), 0.124mg/L, 0.31mg/L and 0.15mg/L (SIDS (2004)), was lower that 90% of the saturated vapour concentration (70ppm) under a saturated vapour pressure of 0.007 kPa (25degC) (CERI Hazard Data 2000-50 (2001)), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm. | |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | No data available |
2 | Skin corrosion/irritation | Category 1A-1C | Danger | H314: Causes severe skin burns and eye damage |
P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment (see ... on this label). P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the description in the report on rabbit skin irritation tests performed in accordance with OECD Test Guideline 404 (SIDS (2004)): "skin corrosive substance." The substance should be placed in Category 1A from the viewpoint of safety if further subclassification is needed. | |
3 | Serious eye damage/eye irritation | Category 1 | Danger | H318: Causes serious eye damage |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
Based on the description in the report on rabbit skin irritation tests performed in accordance with OECD Test Guideline 405 (SIDS (2004)): "eye corrosive substance." | |
4 | Respiratory sensitization | Category 1 | Danger | H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled |
P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P285: In case of inadequate ventilation wear respiratory protection. P501: Dispose of contents/container to ... |
Based on the descriptions of human health effects in CERI Hazard Data 2000-50 (2001), MOE Risk Assessment vol. 2 (2003) and ACGIH (7th, 2001): "The substance induces allergic asthma, irritable pneumonia and contact hypersensitivity." | |
4 | Skin sensitization | Category 1 | Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment (see ... on this label). P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
Based on the description in the report on guinea pig skin sensitization tests (SIDS (2004)): "Positive." Also due to the fact that the substance is classified into "Skin Sensitizing Substance" by the ad hoc committee of the Japanese Society of Occupational Allergy. | |
5 | Germ cell mutagenicity | Not classified | - | - | - | - | Based on the absence of data on multi-generation mutagenicity tests and germ cell mutagenicity tests in vivo, and negative data on somatic cell mutagenicity tests in vivo (micronucleus tests), described in SIDS (2004). |
6 | Carcinogenicity | Classification not possible | - | - | - | - | Classification not possible given the insufficiency of data for use in classification, along with the absence of existing classification. |
7 | Reproductive toxicity | Not classified | - | - | - | - | Based on no evidence of adverse effects on reproductive capacity of parental animals and development of filial generation, described in SIDS (2004). |
8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory system) | Danger | H370: Causes damage to organs (respiratory system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the evidence from animal studies: "the clinical symptoms of inhalation exposure to rats included pulmonary edema and pneumonia" (ATSDR (1998)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. | |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory system) | Danger | H372: Cause damage to organs through prolonged or repeated exposure (respiratory system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the human evidence including "eye, nasal and respiratory irritation, coughing, chest discomfort" (CERI Hazard Data 2000-50 (2001)), and the evidence from animal studies including "tracheal inflammation, turbinate epithelial necrosis, hyperplasia of squamous epithelium in turbinate," "pulmonary epidermal hyperplasia, pneumonitis, coagulation of histiocytes, degeneration of nasal olfactory epithelium, hyperkeratosis, inflammation or ulceration" following inhalation exposure to rats (CERI Hazard Data 2000-50 (2001)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Not classified | - | - | - | - | It was classified into Not classified from 48 hours EC50>=89.1mg/L of the crustacea (Daphnia magna) (SIDS (2004) and others.). |
11 | Hazardous to the aquatic environment (Long-term) | Not classified | - | - | - | - | Since it was not water-insolubility (the water-solubility =117mg/L (PHYSPROP Database, 2005)), and acute toxicity was low, it was classified into Not classified. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website (in Japanese Only) |