GHS Classification Result

Chemical Name：Bromomethane; Methyl bromide
CAS：74-83-9

Result：
ID: 64
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Classified as "gas" according to GHS definition
2 Flammable gases （including chemically unstable gases） Category 1 Danger H220: Extremely flammable gas P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P377: Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P381: Eliminate all ignition sources if safe to do so.
P403: Store in a well-ventilated place. 		Based on the description in ICSC (1999): the lower explosion limit is 10vol%. Not classified as "Flammable/Combustible Gas" by the UN Recommendations on the Transport of Dangerous Goods. A special provision sets forth that the substance is "combustible under limited conditions" (UN#1062 (those not exceeding chloropicrin 2%)). Bromomethane is "regarded as a special case depending on the regulatory purposes" according to the criteria for "flammable/combustible gas" in GHS.
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not classified - - - - Classified into Division 2.3 (UN#1062 (those not exceeding chloropicrin 2%)) (UN Recommendations on the Transport of Dangerous Goods)
5 Gases under pressure Liquefied gas Warning H280: Contains gas under pressure; may explode if heated P410+P403: Protect from sunlight. Store in a well-ventilated place. The boiling point is 4degC (ICSC (1999)), and the critical temperature is 194degC (Merck (13th, 2001)) - i.e., liquefied gas. Classified into Division 2.3 (UN#1062 (those not exceeding chloropicrin 2%)) (UN Recommendations on the Transport of Dangerous Goods)
6 Flammable liquids Not applicable - - - - Classified as "gas" according to GHS definition
7 Flammable solids Not applicable - - - - Classified as "gas" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Classified as "gas" according to GHS definition
9 Pyrophoric liquids Not applicable - - - - Classified as "gas" according to GHS definition
10 Pyrophoric solids Not applicable - - - - Classified as "gas" according to GHS definition
11 Self-heating substances and mixtures Not applicable - - - - Classified as "gas" according to GHS definition
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Classified as "gas" according to GHS definition
13 Oxidizing liquids Not applicable - - - - Classified as "gas" according to GHS definition
14 Oxidizing solids Not applicable - - - - Classified as "gas" according to GHS definition
15 Organic peroxides Not applicable - - - - Classified as "gas" according to GHS definition
16 Corrosive to metals Classification not possible - - - - Test methods applicable to gas substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LD50 (oral route) value of 214mg/kg (SIDS (2003)).
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LC50 (inhalation of gas) value of 600ppm (Agricultural Chemical Registration Data (1980)).
1 Acute toxicity （Inhalation: Vapours） Not applicable - - - - Due to the fact that the substance is "gas" according to the GHS definition and inhalation of its vapour is not expected.
1 Acute toxicity （Inhalation: Dusts and mists） Not applicable - - - - Due to the fact that the substance is "gas" according to the GHS definition and inhalation of its dust/mist is not expected.
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on the report of rabbit skin irritation tests (Agricultural Chemical Registration Data (1979)): "One of six test animals exhibited only slight erythema after 24 hours of application. By 48 hours, the effects had resolved."
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Based on the report of rabbit skin irritation tests (Agricultural Chemical Registration Data (1979)): "Mild irritation of the conjunctiva was observed. All affected animals fully recovered by 24 hours."
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Not classified - - - - Based on negative data on somatic cell mutagenicity tests in vivo (micronucleus tests) although Ames tests were positive (Agricultural Chemical Registration Data (1983)).
6 Carcinogenicity Not classified - - - - There was no increase in tumor incidence in a 2-year carcinogenicity study by dietary admixture (Agricultural Chemical Registration Data (1988)). The substance is classified as Category A4 by ACGIH (2001), Group 3 by IARC (1999) and Category D by EPA (1990).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence of malformation (fused sternebrae, missing gallbladder or missing caudal lobe of lung) in pups at doses causing maternal toxicity in rabbit teratogenicity studies, described in SIDS (2003), IRIS (2005) and CERI Hazard Data 2000-28 (2001).
8 Specific target organ toxicity - Single exposure Category 1 (nervous system, respiratory system, kidney, adrenal gland) Danger H370: Causes damage to organs (nervous system, respiratory system, kidney, adrenal gland) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Inhalation studies in rats and mice provide evidence of reduced locomotor activity/respiratory rate, pneumonia-like changes and kidney/adrenal congestion (Agricultural Chemical Registration Data (1980)).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, heart, testis) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system, heart, testis) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Inhalation studies in rats provide evidence of edema, congestion and necrosis in the brain, fibrosis in the heart and tetraplegia (Agricultural Chemical Registration Data : Methyl Bromide). Evidence of testicular atrophy was also found. The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Not applicable - - - - Due to the fact that the substance is a gas according to the GHS definition.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96 hours LC50=0.3mg/L of he fish (Guppy) (CERI Hazard Data, 2002).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since acute toxicity was Category 1, there was no rapidly degrading (the decomposition by BOD: 15%(Existing Chemical Safety Inspections Data)) and the bio-accumulation potential was low (log Kow=1.19(PHYSPROP Database, 2005), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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