GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Fluorine
CAS：7782-41-4
Result：
| ID: | 62 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 2 | Flammable gases （including chemically unstable gases） | Not classified | - | - | - | - | Non-combustible (ICSC, 2004) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Category 1 (Compressed), Classification not possible (Not compressed) |
|
Danger | H270: May cause or intensify fire; oxidizer (Compressed) |
P370+P376: In case of fire: Stop leak if safe to do so. P220: Keep/Store away from clothing/.../combustible materials. P244: Keep reduction valves free from grease and oil. P403: Store in a well-ventilated place. |
Classified as a powerful oxidant (ICSC (2004)). Those compressed are classified into Division 5.1 (UN#1045 (compressed gas)) by the UN Recommendations on the Transport of Dangerous Goods. Those other than compressed cannot be classified due to lack of data. |
| 5 | Gases under pressure | Compressed gas |
|
Warning | H280: Contains gas under pressure; may explode if heated | P410+P403: Protect from sunlight. Store in a well-ventilated place. | The boiling point is -188degC (ICSC (2004)) and the critical temperature is -129degC (Merck (13th, 2001)), corresponding to "compressed gases" Those compressed are classified into Division 2.3 (UN#1045) (UN Recommendations on the Transport of Dangerous Goods). |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 7 | Flammable solids | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 11 | Self-heating substances and mixtures | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to gaseous substances are not available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Gases） | Category 1 |
|
Danger | H330: Fatal if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the LC50 (4 hours) of 92.5ppm calculated from the testing data of rat LC50 (1-hour inhalation of gas) of 185ppm (PATTY (4th, 2000)). |
| 1 | Acute toxicity （Inhalation: Vapours） | Not applicable | - | - | - | - | Due to the fact that the substance is "gas" according to the GHS definition and inhalation of its vapour is not expected. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Not applicable | - | - | - | - | Due to the fact that the substance is "gas" according to the GHS definition and inhalation of its dust/mist is not expected. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available |
| 3 | Serious eye damage/eye irritation | Category 2A-2B |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
Based on the description in the report on the human effects (PATTY vol.6): "The substance produced irritation of the eye." Although classified into Category 2A-2B given the severity of effects is unknown, it should be placed in Category 2A from the viewpoint of safety, if further subclassification is needed. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | No data available As for the health hazards, refer to "ID479, sodium fluoride, CAS: 7681-49-4." |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | Classification not possible based on expert judgment, given the absence of existing classification. As for the health hazards, refer to "ID479, sodium fluoride, CAS: 7681-49-4." |
| 7 | Reproductive toxicity | Category 2 |
|
Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the evidence of adverse effects on the testes, described in ATSDR (2003), though no data are available on maternal toxicity. As for the health hazards, refer to "ID479, sodium fluoride, CAS: 7681-49-4." |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory system, liver, kidney) |
|
Danger | H370: Causes damage to organs (respiratory system, liver, kidney) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the human evidence including "pulmonary inflammation, coughing, chest tightness, chill, fever, rale, cyanosis and pulmonary edema" (EHC 36 (1984)), "respiratory pain, headache, nausea, polyuria and polydipsia" (HSDB (1998)), and the evidence from animal studies including "hepatocytenecrosis, renal tubular necrosis (in rodents), pulmonary congestion, dyspnea, irritation, alveolar necrosis" (ATSDR (2003)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory system, testis) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, testis) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the evidence from animal studies including "hemorrhage of the lung, pulmonary edema, bronchial inflammation, adverse effects on the respiratory organs (severe irritation of the lung) and degeneration of the testes" (ATSDR (2003)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. |
| 10 | Aspiration hazard | Not applicable | - | - | - | - | Due to the fact that the substance is a gas at ordinary temperatures. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |