GHS Classification Result

Chemical Name:p-Phenylenediamine
CAS:106-50-3

Result:
ID: 59
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Classified as "flammable" by ICSC (2004). Classified into Division 6.1 (UN#1673(o-,m-,p-)) (UN Recommendations on the Transport of Dangerous Goods)
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 400degC (ICSC,2004)
11 Self-heating substances and mixtures Not classified - - - - Classified into Division 6.1 (UN#1673(o-,m-,p-)) (UN Recommendations on the Transport of Dangerous Goods)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the rat LD50 (oral route) value of 80mg/kg representing the lower of the two testing data, 80mg/kg and 98mg/kg (CERI Hazard Data 2001-31 (2002)).
1 Acute toxicity (Dermal) Not classified - - - - Based on the rabbit LD50 (dermal route) of >5,000mg/kg (CERI Hazard Data 2001-31 (2002)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Category 5 - Warning H333: May be harmful if inhaled P304+P312: IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. Based on the rat LC50 (inhalation of dust) value of 920mg/L (4 hours) (CERI Hazard Data 2001-31 (2002)).
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
Based on the description in the report on skin irritation tests in rabbits and guinea pigs (CERI Hazard Data 2001-31 (2002) and DFGOT vol.6 (1994)): "mild to moderate irritation" (though the results are not those of 4-hour application). Also based on the description in DFGOT vol.6 (1994) of human health effects: "mildly irritating."
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
Based on the description in the report on rabbit eye irritation tests (CERI Hazard Data 2001-31 (2002)): "The substance induced moderate conjunctivitis, with effects resolving by 24 hours." Also based on the description of human health effects (CERI Hazard Data 2001-31 (2002), MOE Risk Assessment vol. 3 (2004), PATTY (4th, 1999) and DFGOT vol.6 (1994)): "The substance produces severer symptoms in humans including pain and burning sensation in the eyeball followed by erythema and swelling of lid margin along with chemosis and injection of conjunctiva. In some cases, corneal epithelial erosion, iritis and iridocyclitis, while in more serious cases, corneal ulceration are observed, which may develop into visual impairment and blindness."
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ...
Based on the description of human health effects in CERI Hazard Data 2001-31 (2002), MOE Risk Assessment vol. 3 (2004) and PATTY (4th, 1999): "asthmatic symptoms were observed following exposure to p-phenylenediamine."
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Based on the description in the report on a number of skin sensitization tests in guinea pigs (CERI Hazard Data 2001-31 (2002) and DFGOT vol.6 (1994)): "Skin sensitization: positive." Also based on the description of human health effects in CERI Hazard Data 2001-31 (2002), PATTY (4th, 1999) and DFGOT vol.6 (1994): The substance possesses a potential for sensitization for human skin. Also due to the fact that the substance is classified into "Skin Sensitizing Substance" by the ad hoc committee of the Japanese Society of Occupational Allergy and Japanese Society of Contact Dermatitis, and "Skin Sensitizing Substance: Group 1" by the Japan Society for Occupational Health.
5 Germ cell mutagenicity Not classified - - - - Based on the absence of data on multi-generation mutagenicity tests and germ cell mutagenicity tests in vivo, and negative data on somatic cell mutagenicity tests in vivo (micronucleus tests), described in IARC 16 (1978) and PATTY (4th, 2000).
6 Carcinogenicity Not classified - - - - Due to the fact that the substance is classified as Category A4 by ACGIH (2001) and Group 3 by IARC (1987).
7 Reproductive toxicity Not classified - - - - Based on no evidence of adverse effects on fertility of parental generation and development of filial generation, described in MOE Risk Assessment vol. 3 (2004) and CERI Hazard Data 2001-31 (2002).
8 Specific target organ toxicity - Single exposure Category 1 (muscle, kidney) Danger H370: Causes damage to organs (muscle, kidney) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the human evidence including "acute renal failure due to rhabdomyolysis" (MOE Risk Assessment vol. 3 (2004)), "necrosis of the muscle tissue," "rhabdomyolysis" (CERI Hazard Data 2001-31 (2002)), "rhabdomyolysis" (ACGIH (7th, 2001)), and the evidence from animal studies including "rhabdomyolysis," "necrosis of the skeletal muscles" (CERI Hazard Data 2001-31 (2002)), "died from acute renal failure caused by rhabdomyolysis" (MOE Risk Assessment vol. 3 (2004)), "kidney damage is due to distal renal tubular blockage caused by myoglobin cast" (HSDB (2005)). Although kidney effects are considered secondary, renal failure can be a direct cause of death, so it was included in the target organ list. The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, nervous system, heart), Category 2 (skeletal muscle) Danger
Warning
H372: Cause damage to organs through prolonged or repeated exposure (liver, nervous system, heart)
H373: May cause damage to organs through prolonged or repeated exposure (skeletal muscle)
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the human evidence including "hypertrophy of the liver and spleen, and progressive neurological symptoms were observed; dizziness, gastritis, diplopia, asthenia, desquamative dermatitis were also noted," "jaundice and sub-acute hepatatrophy" (CERI Hazard Data 2001-31 (2002)), and the evidence from animal studies including "degeneration of skeletal muscles" (MOE Risk Assessment vol. 3 (2004)), "degeneration of myocardial parenchyma" (ACGIH (7th, 2001)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Categories 1 and 2
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 96 hours LC50=0.06mg/L of the fish (Fathead Minnows) (CERI Hazard Data, 2002).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Although acute toxicity is Category 1 and bio-accumulation is low (BCF=98(Existing Chemical Safety Inspections Data, )), since there was no rapidly degrading (the decomposition by BOD: 5%(Existing Chemical Safety Inspections Data)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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