GHS Classification Result

Chemical Name：o-Phenylenediamine
CAS：95-54-5

Result：
ID: 58
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Classified as flammable according to ICSC (2004). Classified into Division 6.1 (UN#1673 (o-,m-,p-)) (UN Recommendations on the Transport of Dangerous Goods).
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Classified into Division 6.1 (UN#1673 (o-,m-,p-)) (UN Recommendations on the Transport of Dangerous Goods).
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available (melting point: 103-104degC (ICSC, 2002), test temperature: 140degC)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 510mg/kg, calculated from the testing data of rat LD50 (oral route) of 510mg/kg, 3,000mg/kg (CERI Hazard Data 2001-31 (2002)), 660mg/kg and 1,284mg/kg (ACGIH (7th, 2001)).
1 Acute toxicity （Dermal） Classification not possible - - - - Insufficient data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LC50 (inhalation of dust) value of 0.15mg/L (4 hours) (ACGIH (7th, 2001)).
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on the description in the report on rabbit skin irritation tests (4 hour application) (CERI Hazard Data 99-3 (2000)): "mild irritation." Also based on the description of the human health effects (MOE Risk Assessment vol. 3 (2004)): "mildly irritating to the skin." The substance is thus classified as Category 3, though the results of a dermal irritation test in rabbits (4 hours) reported in DFGOT vol.6 (1994) suggest no irritation.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the description in the report on rabbit eye irritation tests (DFGOT vol.6 (1994), CERI Hazard Data 99-3 (2000) and ACGIH (7th, 2001)): The substance produced "mild irritation." Also based on the description of the human health effects (MOE Risk Assessment vol. 3 (2004)): "irritating to the human eye."
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the positive results in a number of skin sensitization studies with guinea pigs (CERI Hazard Data 2001-31 (2002) and DFGOT vol.6 (1994)) and the evidence of skin sensitization in humans reported in MOE Risk Assessment vol. 3 (2004) and DFGOT vol.6 (1994). Furthermore due to the fact that the substance is classified as a "Skin Sensitizing Substance" by the ad hoc committee of the Japanese Society of Occupational Allergy, and "Skin Sensitizing Substance: Group 1" by the Japan Society for Occupational Health.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on negative data on multi-generation mutagenicity tests, the absence of data on germ cell mutagenicity tests in vivo and germ cell genotoxicity in vivo tests, and positive data on somatic cell mutagenicity tests in vivo (micronucleus tests and chromosome aberration tests), described in CERI Hazard Data 99-3 (2000), DFGOT vol. 2 1 (2005) and NTP DB (Access on March 2006).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Due to the fact that the substance is classified as Category A3 by ACGIH (2001).
7 Reproductive toxicity Not classified - - - - Based on expert judgment since no evidence of reproductive toxicity was found in rat teratogenicity studies, described in MOE Risk Assessment vol. 3 (2004) and PATTY (4th, 2000).
8 Specific target organ toxicity - Single exposure Category 1 (blood system), Category 2 (respiratory system, nervous system, kidney, muscle, liver) Danger
Warning 		H370: Causes damage to organs (blood system)
H371: May cause damage to organs (respiratory system, nervous system, kidney, muscle, liver) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. 		Based on the human evidence: "the substance is irritating to the eye; slightly irritating to the skin and respiratory tract; has effects on blood and may form methemoglobin" (MOE Risk Assessment vol. 3 (2004)), "indifference, rhabdomyolysis, LDH - APAT -, elevated Aldolase Glutamat Amino Transferase, acute renal failure, popliteal discoloration, damage to the central nervous system/muscle/liver," "renal tubular degeneration, renal interstitial edema, hepatocyte necrosis and bronchial pneumonia," "auditory disturbance, dyspnea and nephropathy" (IUCLID (2000)). Also based on the evidence from animal studies including "methemoglobin formation" (ACGIH (7th, 2001)), "ataxia, changes in salivary gland function or structure, and hematuria following dermal administration" (RTECS (2005)), "slight irritation of the nasal mucosa" (DFGOT vol.13 (1999)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Categories 1 and 2.
9 Specific target organ toxicity - Repeated exposure Category 2 (respiratory system, heart, kidney) Warning H373: May cause damage to organs through prolonged or repeated exposure (respiratory system, heart, kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "nasal congestion, nasal irritation, dyspnea, blood Heinz bodies," "angitis, right coronary artery infarction, pulmonary congestion, renal hypertrophy and glomerulonephritis" (IUCLID (2000)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 72 hours ErC50=0.82mg/L of the algae (Selenastrum) (MOE Eco-Toxicity Tests of Chemicals, 2001).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Although acute toxicity is Category 1 and bio-accumulation is low (log Kow=0.15(PHYSPROP Database, 2005)), since there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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