GHS Classification Result

Chemical Name:ethion
CAS:563-12-2

Result:
ID: 53
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Classification not possible - - - - No data available by regulated examination methods, though it is flammable (ICSC(J), 1998)
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - No data available
9 Pyrophoric liquids Classification not possible - - - - No data available
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Classification not possible - - - - No data available
13 Oxidizing liquids Classification not possible - - - - No data available
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Calculated based on rat LD50 value: 27mg/kg (ACGIH, 2003, ATSDR, 2001), 21mg/kg (ACGIH, 2003), and 208mg/kg (PATTY 4th, 1993). Since the calculation values were lower than the lowest values of these values, 21mg/kg of the lowest values was adopted, and set it to Category 2.
1 Acute toxicity (Dermal) Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was set as Category 2 based on the lowest value of 62mg/kg of a rat. (Rat LD50 values: 62mg/kg (ACGIH, 2003, ATSDR, 2001), 838mg/kg (ACGIH, 2003), and rabbit LD50 value: 915mg/kg (ACGIH, 2003, PATTY 4th, 1993))
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
There are rat LC50 (4 hours) value: 0.864mg/L (ACGIH, 2003) and 0.45mg/L (ACGIH, 2003, ATSDR, 2001). Adopting the lower value, it was set as Category 2
2 Skin corrosion/irritation Not classified - - - - Since ACGIH (2003) reports that it slightly irritates skin of the rabbit, it was judged not to match the irritation criteria and was classified as out of Category.
3 Serious eye damage/eye irritation Not classified - - - - From description that the eye of the rabbit was stimulated only slightly (only slightly) on ACGIH (2003), it was judged that it was not adapted for basis of irritation, and was set as the outside of Category.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Not classified - - - - There are negative results from the dominant lethal test in mice, which is an in vivo multi-generation mutagenicity test using germ cells (JMPR, 1972) and the chromosome aberration test using rat bone-marrow cells, which is an in vivo mutagenicity test using somatic cells (JMPR, 1986). So the substance was regarded as outside the categories
6 Carcinogenicity Not classified - - - - Since it was classified into A4 (ACGIH, 2003) according to ACGIH, it was set as the outside of Category.
7 Reproductive toxicity Not classified - - - - In the pregnancy peroral administration using rat and rabbit, and the third generation reproduction study using rat (ACGIH (2003), IRIS (2006), ATSDR (2001)), there was no clear reproductive toxicity in the dose causing general toxicity for parent animals. So it was considered as on the outside of Categry.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
The substance was classified as Category 1 (nervous system). Based on the reports that cholinergic effects, such as tremors and convulsions, were observed at the dosage within the guidance values for Category 1 in an oral administration test using rats in ATSDR (2001), and that symptoms for neurotoxicity were observed in a case of accidental ingestion by an infant, and that the major target organs of acute toxicity are the central and peripheral nervous systems.
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Dut to the descriptions that Cholinergic symptoms by cholinesterase inhibition, such as ataxia and nerve tremor in the oral study using dog (ACGIH, 2003, PATTY 4th, 1993, IRIS, 2005, ATSDR, 2001) , the descriptions that the decrease in activity of brain cholineesterase in the oral study using rat (IRIS, 2005, ATSDR, 2001) and in the dermal administration test using rabbit (ACGIH, 2003, ATSDR, 2001) were observed with the given dose of the guidance value range of Category 1, and the description that the observation of cholinergic toxic phenomena in the repeated episodes of exposure to human (ACGIH (2003) and IRIS (2005)), it was classified into Category 1 (nerve system).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 50= 0.056ppb of 48-hour EC of Crustacea (Daphnia magna) (AQUIRE, 2003).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity is Category 1, supposed not rapidly degrading (BIOWIN), and bioaccumulative (log Kow=5.07 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


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