GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Picric acid
CAS：88-89-1
Result：
| ID: | 52 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Division 1.1 |
|
Danger | H201: Explosive; mass explosion hazard |
P370+P380: In case of fire: Evacuate area. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P230: Keep wetted with ... P240: Ground/bond container and receiving equipment. P250: Do not subject to grinding/shock/.../friction. P280: Wear protective gloves/protective clothing/eye protection/face protection. P372: Explosion risk in case of fire. P374: Fight fire with normal precautions from a reasonable distance. P401: Store ... P501: Dispose of contents/container to ... |
Based on the classification by the UN Recommendations on the Transport of Dangerous Goods (Division 1.1D, UN#0154) (no other data available). The substance contains nitro groups, with its oxygen budget calculated at -45. Its kick-off temperature and decomposition energy stand at 118degC and 5.1kJ/g, respectively, according to the Explosion Safety Database (2005) - i.e., explosives. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 7 | Flammable solids | Not classified | - | - | - | - | Classified into Division 1.1D (UN#0154) (UN Recommendations on the Transport of Dangerous Goods) |
| 8 | Self-reactive substances and mixtures | Not classified | - | - | - | - | Classified as "explosives" |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | Not pyrophoric when in contact with air at ordinary temperatures; the auto-ignition temperature is 300degC (ICSC, 1999) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available - melting point: 122degC (ICSC, 1999), test temperature: 140degC |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 14 | Oxidizing solids | Not classified | - | - | - | - | No data available, though being organic compounds containing oxygen bound to carbon and hydrogen. Not classified, based on the classification by UN Recommendations on the Transport of Dangerous Goods (Division 1.1D, UN#0154) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 3 |
|
Danger | H301: Toxic if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the LD50 value of 214 mg/kg calculated from the testing data of rat LD50 (oral route) of 492mg/kg (Report by the Ministry of Health, Labour and Welfare (2001)), 283 mg/kg (Report by the Ministry of Health, Labour and Welfare (2001)), 200mg/kg (DFGOT vol. 17 (2002)) and 290mg/kg (DFGOT vol. 17 (2002)). |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | Insufficient data available |
| 3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
Based on the results of rabbit eye irritation tests (ACGIH 7th (2001), DFGOT vol.17 (2002)): The irritation subsides within 24 hours. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Category 1 |
|
Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
Based on the results of guinea pig skin sensitization tests (CERI Hazard Data 98-30 (1999), DFGOT vol.17 (2002)) (skin sensitization: positive) and those of human skin sensitization teses (CERI Hazard Data 98-30 (1999), ACGIH (7th, 2001), DFGOT Vol.17 (2002)) (skin sensitization: positive). |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Insufficient data available |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system, blood system, kidney, liver), Category 3 (respiratory tract irritation) |
|
Danger Warning |
H370: Causes damage to organs (central nervous system, blood system, kidney, liver) H335: May cause respiratory irritation (respiratory tract irritation) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
Based on the human evidence including "headache, dizziness, dark urine and albuminuria, and if ingested in large quantities, destruction of red blood cells, gastroenteritis, hemorrhagic nephritis, acute hepatitis" (CERI Hazard Data 98-30 (1999)), "irritation to the eye and nasal mucosal" (MOE Risk Assessment vol. 3 (2004)), and the evidence from animal studies including "tremor, tonic/clonic spasm" (CERI Hazard Data 98-30 (1999)), "a decrease in locomotor activity, gait abnormality, clonic spasm, chromaturia (dark yellow), coloring of skin (yellow), abdominal position procumbent, decubitus position" (2001 Report by the Ministry of Health, Labour and Welfare). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (blood system), Category 2 (testis) |
|
Danger Warning |
H372: Cause damage to organs through prolonged or repeated exposure (blood system) H373: May cause damage to organs through prolonged or repeated exposure (testis) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the evidence from animal studies including "anemia due probably to hemolysis and seminiferous tubular atrophy" (2001 Report by the Ministry of Health, Labour and Welfare). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 3 | - | - | H402: Harmful to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It was classified into Category 3 from 96 hours LC50=19.7mg/L of the crustacea (Mysid Shrimp)) (CERI Hazard Data, 1999). |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - | - | Although the acute toxicity was Category 3, judging from the NOEC=5mg/L during 21 days of the crustacea (Daphnia magna) (ECETOC TR91, 2003), it was classified into Not classified. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |