GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Nickel carbonyl
CAS：13463-39-3
Result：
| ID: | 49 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | Containing no atom groups with explosive properties |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 6 | Flammable liquids | Category 2 |
|
Danger | H225: Highly flammable liquid and vapour |
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
The flashing point is -20degC (ICSC, 2002) (closed cup flash test) and the boiling point is 43degC which is classified into Category 2. Classified into Class 3 and Category 6.1 (UN#1259) (UN Recommendations on the Transport of Dangerous Goods) |
| 7 | Flammable solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Containing no atom groups with explosive or self-reactive properties |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Classified into Class 3 and Category 6.1 (UN#1259) (UN Recommendations on the Transport of Dangerous Goods |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Stable to water; insoluble (ICSC, 2002) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing no oxygen, fluorine and chlorine |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to gaseous substances are not available - boiling point: 43degC (ICSC,2002), test temperature: 55degC |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected. |
| 1 | Acute toxicity （Inhalation: Vapours） | Category 1 |
|
Danger | H330: Fatal if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the rat LC50 (4 hours) value of 12ppm, calculated from the testing data of rat LC50 (inhalation of vapour) of 35ppm (0.5 hours), was lower than 90% of the saturated vapor concentration (528,000ppm) under a saturated vapour pressure of 400mmHg (25.8degC) (equivalent to 53,300Pa at 25.8degC) (HSDB, 2005), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Category 2 |
|
Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse. |
Based on the following human evidence found in EHC 108 (1991): "Primary skin irritation reactions to nickel salts in solution were observed when human volunteers were patch tested. When aqueous solutions of nickel chloride were applied to the back, the threshold concentrations for irritancy were 1% with occlusion and 10% without occlusion." |
| 3 | Serious eye damage/eye irritation | Category 1 |
|
Danger | H318: Causes serious eye damage |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
Based on the following human evidence found in HSDB, 2005: "Vapor is irritating to eyes, nose, and throat. Liquid will burn the skin and eyes", which should be considered as "irreversible damage to eyes" from the viewpoint of safety. |
| 4 | Respiratory sensitization | Category 1 |
|
Danger | H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled |
P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P285: In case of inadequate ventilation wear respiratory protection. P501: Dispose of contents/container to ... |
Based on the following epidemiological observation provided by EHC 108 (1991): "A chemical engineer, who had been exposed for a long period to low levels of nickel carbonyl, developed asthma and Loffler's syndrome. In addition to pulmonary infiltrations and eosinophilia, which are markers in Loffler's syndrome, the patient had an eczematous dermatitis of the hands." |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Based on the absence of data on heritable mutagenicity tests, germ/somatic cell mutagenicity tests in vivo and in vitro mutagenicity tests and positive data on somatic cell genotoxicity tests in vivo (DNA binding tests), described in EHC 108 (1991) and IARC 49 (1990). |
| 6 | Carcinogenicity | Category 1A |
|
Danger | H350: May cause cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Due to the fact that the substance is classified as Group 1 (as nickel compounds) by IARC(1990)and Category K by NTP (2005). |
| 7 | Reproductive toxicity | Category 2 |
|
Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the evidence of malformations (anophthalmia, microphthalmia, cystic lung, hydronephrosis, exencephalia, fused ribs and cleft palate), and hemorrhage in the chorionic cavity in teratogenicity tests on rats and guinea pigs, described in IARC 49 (1990) and EHC 108 (1990), and the absence of description of the effects on parent animals. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system, liver, respiratory system, kidney, adrenal gland, heart, spleen, pancreas) |
|
Danger | H370: Causes damage to organs (central nervous system, liver, respiratory system, kidney, adrenal gland, heart, spleen, pancreas) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the human evidence including "frontal headache, dizziness, nausea, vomiting, insomnia, irritation followed by pulmonary symptoms" and "parenchymatous degeneration in the liver, kidneys, adrenal and spleen, cerebral edema and dot hemorrhage in the brain" (EHC 108, 1991) and the evidence from animal studies including "interstitial pneumonitis associated with focal atelectasis and necrosis, parenchymatous degeneration associated with focal necrosis in the liver, spleen, kidneys and pancreas" and "inflammation, atelectasis and interstitial fibroplasia in the lungs; congestion and hemorrhage in the kidney and adrenal" (CICAD 61, 2004). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | No data available |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |