GHS Classification Result

Chemical Name：Trichloronitromethane; Chloropicrin
CAS：76-06-2

Result：
ID: 42
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Cannot be classified due to lack of data, though containing nitro groups with its oxygen budget calculated at 0. A study shows that the substance packaged in amounts exceeding the maximum quantity is liable to undergo an explosion by impact (Bretherick (J) (5th, 1998)), and hence it could be classified into "Explosives." Classified into Division 6.1 (UN#1580) (UN Recommendations on the Transport of Dangerous Goods)
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Not classified - - - - Non-combustible (ICSC, 1999)
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not classified - - - - No data available, thoughtThe substance contains chemical groups associated with explosive properties that contain nitro groups. Classified into Division 6.1 (UN#1580) (UN Recommendations on the Transport of Dangerous Goods)
9 Pyrophoric liquids Not classified - - - - Non-combustible (ICSC, 1999).
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (ICSC,1999)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not classified - - - - No data available, though being organic compounds containing oxygen bound to elements other than carbon and hydrogen. Classified into Division 6.1 (UN#1580) (UN Recommendations on the Transport of Dangerous Goods)
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Not classified - - - - Classified into Division 6.1 (UN#1580) (UN Recommendations on the Transport of Dangerous Goods)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LD50 (oral route) value of 250mg/kg (MOE Risk Assessment vol. 2 (2003)).
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LC50 (4 hour inhalation of vapour) of 6.6ppm (PATTY (4th, 1999)) representing the lower of the two testing data, 14.4ppm (MOE Risk Assessment vol. 2 (2003)) and 6.6ppm, was lower than 90% of the saturated vapour concentration (22,400ppm) under a saturated vapour pressure of 2.26kPa (20degC), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values of gas.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on the descriptions in the report on epidemiological studies of human exposure (CERI Hazard Data 2000-3 (2001)): "The substance causes irritation of the skin, eye and mucous membranes of the respiratory tract/digestive organs" "dermatitis was observed following dermal exposure." Also due to the fact that the substance is assigned to R36/37/38 by EU classification.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Based on the descriptions in the report on epidemiological studies of human exposure (CERI Hazard Data 2000-3 (2001)): "Inadvertent eye contact resulted in severe edema." The substance is thus considered severely irritating to the eye. Although classified as Category 1-2A, given the absence of data on reversibility, the substance should be placed in Category 1 from the viewpoint of safety.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - NTP DB (Access on Apr., 2006) and CERI Hazard Data 2000-3 (2001) contain descriptions on the substance giving positive data on in vitro mutagenicity tests (mutation and chromosome aberration), but the results were not definitive. Moreover, no data are available on in vivo mutagenicity studies.
6 Carcinogenicity Not classified - - - - Due to the fact that the substance is classified as Category A4 by ACGIH (2001).
7 Reproductive toxicity Classification not possible - - - - Classification not possible due to the insufficiency of data (no data are available on parental animals).
8 Specific target organ toxicity - Single exposure Category 1 (nervous system, respiratory system, blood system) Danger H370: Causes damage to organs (nervous system, respiratory system, blood system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the human evidence including: "coughing, lacrimation, runny nose, bronchitis and nasal inflammation were observed in members of a family" (DFGOT vol.6 (1994)), "died from pulmonary edema when sprayed in the face with chloropicrin, " (CERI Hazard Data 2000-3 (2001)), "developed a dry cough with erythema of the nasal/pharyngeal mucosa and edema" (ACGIH (7th, 2002)), "irritation of the upper respiratory tract accompanied by lacrimation, runny nose, coughing, headache and dyspnea; methemoglobin formation was detected among those exposed to higher doses" (DFGOT vol.6 (1994)). Also based on the evidence from animal studies including "accelerated respiration, reduced locomotor activity, conjunctival injection, inspiratory dyspnea, abdominal bloating due to retention of the air in the gastrointestinal tract by swelling and stenosis of the respiratory tract, pulmonary congestion, pneumonia and pulmonary edema" (CERI Hazard Data 2000-3 (2001)), "hemorrhagic pulmonary edema (DFGOT vol.6 (1994)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system, central nervous system), Category 2 (blood system) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, central nervous system)
H373: May cause damage to organs through prolonged or repeated exposure (blood system) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "prolonged exposure to high doses may cause death from pulmonary edema" (CERI Hazard Data 2000-3 (2001)), "exhibited clinical symptoms such as lacrimation, coughing, dizziness, headache, nausea, retching and fatigue" (HSDB (2005)), and the evidence from animal studies including "decreased hemoglobin and hematocrit levels" (CERI Hazard Data 2000-3 (2001)), "damage to the nasal cavity (such as inflammation and atrophy of the olfactory epithelium) and the lung (such as hemorrhage and hyperplasia of the bronchoalveolar smooth muscle)" (MOE Risk Assessment vol. 4 (2005)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96 hours LC50=0.0165mg/L of the fish (Rainbow Trout) (CERI Hazard Data, 2001).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Although acute toxicity is Category 1 and bio-accumulation is low (log Kow=2.09(PHYSPROP Database, 2005)), since there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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