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GHS Classification Result

Chemical Name：Selenium
CAS：7782-49-2

Result：


ID:	37
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	Containing no chemical groups with explosive properties
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
5	Gases under pressure	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
6	Flammable liquids	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
7	Flammable solids	Classification not possible	-	-	-	-	Classification not possible, because of the unidentified configuration and the absence of data. The substance is combustible according to ICSC (2004) and, as far as metals are concerned, the finer the particles, the more dangerous they are, according to Sax (11th, 2004). Metal powder (combustibles, and excluding those with specific product names) is classified into Division 4.1, Packing Group II and III (UN#3089), by the UN Recommendations on the Transport of Dangerous Goods.
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	Containing no chemical groups with explosive or self-reactive properties
9	Pyrophoric liquids	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
10	Pyrophoric solids	Classification not possible	-	-	-	-	No data available
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	No data available
12	Substances and mixtures which, in contact with water, emit flammable gases	Classification not possible	-	-	-	-	Classified as metalloids. Selenium reacts with water at 50degC, with the evolution of selenious acid and flammable hydrogen, according to ICSC (2004). However, classification is not possible due to lack of data on the maximum generation rate of hydrogen gas at ambient temperature.
13	Oxidizing liquids	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
14	Oxidizing solids	Not applicable	-	-	-	-	Inorganic compounds containing no oxygen and halogen
15	Organic peroxides	Not applicable	-	-	-	-	Not organic compounds
16	Corrosive to metals	Classification not possible	-	-	-	-	Test methods applicable to solid substances are not available

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Based on the rat LD50 (oral route) value of 6,700mg/kg (CERI Hazard Data 2001-38 (i) (2002)).
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	Insufficient data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	Insufficient data available
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	Insufficient data available
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	Insufficient data available, though CERI Hazard Data 2001-39(i)(2002)reports epidemiological evidence of human exposure: "irritating." to labor exposed high level of Selenium for a short time.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Classification not possible	-	-	-	-	No data available
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	No data available
6	Carcinogenicity	Not classified	-	-	-	-	Due to the fact that the substance is classified as Category D by EPA (1993) and Group 3 by IARC (1987).
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the evidence of adverse effects on reproduction and pups, described in EHC 58 (1986) (though no data on parental toxicity are available).
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system, respiratory system)		Danger	H370: Causes damage to organs (nervous system, respiratory system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the human evidence including "vomiting, diarrhea, abdominal pain, numbness of hands, abnormal menstrual bleeding and abnormal dehairing" (HSDB (1998)), and the evidence from animal studies including "pneumonitis" (CERI Hazard Data 2001-39 (i) (2002)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1 (respiratory organs) Note: As for acute toxicity of inorganic selenium compounds, "clinical findings include vomiting, diarrhea, laboured breathing, weakness, unstable gait and coma, while histological findings include pulmonary edema, necrosis of the liver, degeneration of the skeletal muscles, hydropic degeneration of renal tubules, swelling and rupture of the myocardial mitochondria" (PATTY (4th, 2000)).
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system, respiratory system, liver)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (nervous system, respiratory system, liver)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Based on the human evidence including "peripheral nerve conduction velocity, peripheral nerve paralysis, neurological symptoms including pain and abnormal reflex, consciousness disorder, spasm, paralysis, changes in motor activity" (CERI Hazard Data 2001-39 (i) (2002)) and "chronic bronchitis or moderate pulmonary emphysema" (EHC 58 (1986)), and the evidence from animal studies including "cirrhosis" (CERI Hazard Data 2001-39 (i) (2002)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1 (liver).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Classification not possible	-	-	-	-	Classification not possible due to lack of data
11	Hazardous to the aquatic environment （Long-term）	Category 4	-	-	H413: May cause long lasting harmful effects to aquatic life	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	Although L(E) C50 <=100 mg/L data existed, since it was metal and the behavior in the water was unknown, it classified into Category 4.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model SDS by MHLW	MHLW Website （in Japanese Only）