GHS Classification Result

Chemical Name:1,1-Dimethyl-4,4-bipyridinium dichloride
CAS:1910-42-5

Result:
ID: 34
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-combustible (ICSC (J) (2001))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC (J), 2001)
11 Self-heating substances and mixtures Not classified - - - - Not combustible (ICSC(J) (2001))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water. (The value of aqueous solubility is acquired. Moreover, the this product is marketed also as wettable powders (herbicide).)
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available. Corrosive to metals (Merck, 13th, 2001; ICSC(J), 2001)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Category 3 based on SPECIES: Rat (male); ENDPOINT: LD50; VALUE: 223mg/kg; REFERENCE SOURCE: Agricultural Chemicals Registration Data(1991)
1 Acute toxicity (Dermal) Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was set as Category 2 according to female rat LD50 = 79mg/kg of Agricultural Chemical Registration Data (1991).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable - - - - This product has very low vapor pressure (less than 0.01mPa at 25degC), and since vapor exposure was considered to be difficult, it was out of classification.
1 Acute toxicity (Inhalation: Dusts and mists) Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
It was set as Category 1 rat LC50 = 0.00084mg/L (Agricultural Chemical Registration Data (1991)).
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
In Agricultural Chemical Registration Data (1991), several reports describe that the moderate stimulativeness was seen in 20% paraquat solution (several additive agents other than water are included) on rabbits skin irritation study, and redness and sloughing were seen in the pesticide formulations acute dermal toxicity tests on rats, etc. Therefore, it was thought to have relatively strong skin stimulativeness and classified as Category 2.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
Moderate stimulativeness was seen in the eye stimulativeness examination of the rabbit with the 20% paraquat solution (several sorts of additive agents other than aqueous were included) in Agricultural Chemical Registration Data (1991). And it did not recover completely at the end of a nine-day observation period, it was set as Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Classified as out of category because the skin sensitization test (Maximization method) using guinea pigs found no skin sensitization in Agricultural Chemical Registration Data (2004).
5 Germ cell mutagenicity Not classified - - - - There are 3 negative reports of in vivo mutagenicity tests using somatic cells in Agricultural Chemical Registration Data (1991) (2 bone-marrow chromosome aberration tests (one of these tests had statistically significant difference) and 1 bone-marrow micronucleus test). So the substance was regarded as outside the categories. The in vivo liver UDS test result was negative as well.
6 Carcinogenicity Not classified - - - - In the carcinogenicity tests of rat and mouse of Agricultural Chemical Registration Data (1991), neoplastic lesions relevant to the this product were not observed. So it was set as the outside of Category. In addition, it is classified into C (considerable out of Category) according to IRIS (1993).
7 Reproductive toxicity Not classified - - - - In the three-generation reproductive toxicity test of the rat, and in the teratogenicity test of rats and mice (Agricultural Chemical Registration Data (1991)), there was no obvious effect involved with the material, and they were considered as on the outside of Categry.
8 Specific target organ toxicity - Single exposure Category 1 (lung, kidney, liver) Danger H370: Causes damage to organs (lung, kidney, liver) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
The substance was classified as Category 1 (lungs, kidneys, liver). Because effects on the lungs regardless of the exposure routes (oral, percutaneous and inhalational) were observed in a rat acute toxicity test in Agricultural Chemical Registration Data (1991). And there is a report of effects on the kidneys and liver as well as lungs in an accident case with humans in ACGIH (7th, 2001) of Priority 1 document (there is a similar report in ICSC(J) of Priority 2 document (2001)).
9 Specific target organ toxicity - Repeated exposure Category 2 (lung) Warning H373: May cause damage to organs through prolonged or repeated exposure (lung) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In the rat repeated exposure test (feeding administration) of Agricultural Chemical Registration Data (1991), the lesion of the lung relevant to doses of this product was observed, and it was classified into Category 2 (lung) from comparison with the dosage in the toxicity appeared and the guidance value.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 96-hour ErC50=0.6mg/L of algae (Green algae) (Agricultural Chemical Registration Data, 2004).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity was Category 1, not rapidly degrading (BOD: 0% (existing chemical safety inspections data)), though less bioaccumulative (BCF=0.3(existing chemical safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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