GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Cyclohexylamine
CAS：108-91-8
Result：
| ID: | 30 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | Containing no chemical groups with explosive properties |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 6 | Flammable liquids | Category 3 |
|
Warning | H226: Flammable liquid and vapour |
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
The flash point is 28degC (c.c.) (ICSC (2002)). Classified into Classes 3 and 8 (UN#2357) (UN Recommendations on the Transport of Dangerous Goods). |
| 7 | Flammable solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Containing no chemical groups with explosive or self-reactive properties |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 293degC (ICSC, 2003) |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing no oxygen, fluorine and chlorine |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Cannot be classified due to lack of data, though it "acts on aluminum, copper and zinc" according to ICSC (2003). Classified into "Class 8: corrosive substances" by the UN Recommendations on the Transport of Dangerous Goods (UN#2357). However, the category includes skin corrosivity, and hence does not allow the metal corrosivity of cyclohexylamine to be determined. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 3 |
|
Danger | H301: Toxic if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the rat LD50 (oral route) value of 156mg/kg representing the lower of the two testing data, 800mg/kg and 156mg/kg (CERI Hazard Data 2001-54 (2002)). |
| 1 | Acute toxicity （Dermal） | Category 3 |
|
Danger | H311: Toxic in contact with skin |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the rabbit LD50 (dermal route) of 277mg/kg (CERI Hazard Data 2001-54 (2002)). |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected. |
| 1 | Acute toxicity （Inhalation: Vapours） | Category 3 |
|
Danger | H331: Toxic if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P311: Call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the rat LC50 (4 hours) value of 2,000ppm, calculated from the testing data of rat LC50 (16-hour inhalation exposure) of 1,000ppm (CERI Hazard Data 2001-54 (2002)), was lower than 90% of the saturated vapour concentration (2,480ppm) under a saturated vapour pressure of 250Pa (20degC), the substance is considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Category 1A-1C |
|
Danger | H314: Causes severe skin burns and eye damage |
P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the description in the report on rabbit skin irritation tests (CERI Hazard Data 2001-54 (2002)): "Corrosive" (though exposure duration is unknown). Also due to the fact that the substance is assigned to "C; R34: Corrosive" by EU Risk Phrase. Although classified into Categories 1A-1C, the substance should be placed in Category 1A from the viewpoint of safety, if further subclassification is needed. |
| 3 | Serious eye damage/eye irritation | Category 1 |
|
Danger | H318: Causes serious eye damage |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
Based on the description in the report on rabbit eye irritation tests (CERI Hazard Data 2001-54 (2002)): "Corrosive." |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
| 5 | Germ cell mutagenicity | Category 1B |
|
Danger | H340: May cause genetic defects |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on positive data on multi-generation mutagenicity tests (dominant lethal tests) and germ cell mutagenicity tests in vivo (chromosome aberration tests), described in IARC 73 (1999), CERI Hazard Data 2001-54 (2002) and MOE Risk Assessment vol.3 (2004). |
| 6 | Carcinogenicity | Not classified | - | - | - | - | Due to the fact that the substance is classified as Category A4 by ACGIH (2001) and Group 3 by IARC (1987). |
| 7 | Reproductive toxicity | Category 2 |
|
Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the evidence of adverse effects on the testes and decreased weaning indices, described in CERI Hazard Data 2001-54 (2002) and MOE Risk Assessment vol.3 (2004), although no data are available on parental toxicity. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (blood system, nervous system, respiratory system), Category 3 (narcotic effects) |
|
Danger Warning |
H370: Causes damage to organs (blood system, nervous system, respiratory system) H336: May cause drowsiness or dizziness (narcotic effects) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
Based on the human evidence including "a slight degree of methemoglobin formation and sympathetic nervous stimulation" (CERI Hazard Data 2001-54 (2002)), "dizziness, somnolency, anxiety and nausea were observed in subjects, one of whom exhibited unintelligible articulation, vomiting and mydriasis" (MOE Risk Assessment vol.3 (2004)), the evidence from animal studies including "very strong irritation" (CERI Hazard Data 2001-54 (2002)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (blood system, thyroid, heart, kidney, respiratory system), Category 2 (testis) |
|
Danger Warning |
H372: Cause damage to organs through prolonged or repeated exposure (blood system, thyroid, heart, kidney, respiratory system) H373: May cause damage to organs through prolonged or repeated exposure (testis) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the evidence from animal studies including "decreases in hemoglobin concentration/RBC count, reticulocytosis, hypothyroidism, fatty/granule degeneration of myocardium and kidney, inflammatory changes in the trachea and lung" (CERI Hazard Data 2001-54 (2002)), "focal vacuolation of Sertoli cells and degeneration/loss of sperm mother cells" (CERI Hazard Data 2001-54 (2002)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1 (blood system, heart, kidneys, respiratory organs) and Category 2 (testes). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 3 | - | - | H402: Harmful to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It was classified into Category 3 from 96 hours LC50=33mg/L of the fish (Oryzias Latipest) (MOE eco-toxicity tests of chemicals, 1997). |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - | - | Since there was rapidly degrading (the decomposition by BOD: 61.6% (Existing Chemical Safety Inspections Data)) and the bio-accumulation was low (log Kow=1.49 (PHYSPROP Database, 2005)), it was claasified into Not classified. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |