GHS Classification Result

Chemical Name：Chloroform
CAS：67-66-3

Result：
ID: 24
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no atom groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Not classified - - - - Non-combustible (ICSC,2004)
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Containing no atom groups with explosive or self-reactive properties
9 Pyrophoric liquids Not classified - - - - Non-combustible (ICSC,2004)
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (ICSC,2004)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing chlorine (but not oxygen and fluorine), with the chlorine bound to carbon and hydrogen (but not to other elements)
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Not classified - - - - Classified into Division 6.1 (UN Recommendations on the Transport of Dangerous Goods, UN#1888)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 635 mg/kg calculated from the testing data of rat LD50 (oral route) of 450 mg/kg, 1,200 mg/kg, 908 mg/kg, 2,000 mg/kg, 450 mg/kg, 1,117 mg/kg (EHC 163, 1994).
1 Acute toxicity （Dermal） Classification not possible - - - - Insufficient data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Insufficient data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence of "slight congestion in the skin, moderate skin necrosis and incrustation" (EHC 163, 1994) from the rabbit skin irritation test, although the substance should be placed in Category 1A from the viewpoint of safety.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Based on the evidence of "Severe eye irritation, with mydriasis and keratitis in all rabbits. Translucent zones in the cornea were observed in four animals and a purulent hemorrhagic discharge was also reported (number of rabbits unknown). The effects had disappeared 2-3 weeks after application, except for one rabbit that still showed corneal opacity after 3 weeks" (EHC 163, 1994) from the rabbit eye irritation test.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the absence of data on heritable mutagenicity tests, germ cell mutagenicity tests in vivo and germ cell genotoxicity tests in vivo and positive data on somatic cell mutagenicity tests in vivo (micronucleus and chromosome aberration tests), described in CERI-NITE Hazard Assessment No.16 (2004), IARC 73 (1999), CaPSAR (2001), EHC 163 (1994), DFGOT Vol. 14 (2000) and NTP DB (Access on December 2005).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Due to the fact that the substance is classified as Category R by NTP (2005), Group 2B by IARC (1999), Category 3 by EU Risk Phrase, Category A3 by ACGIH (2001), Category B2 by EPA (1986) and Category 2B by the Japan Society for Occupational Health.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence of a decline in fertility, a decreas in crown-rump length, delayed calcification of the skull and lumbar ribs, an increase in cleft palate, malformation of the interperietal bone, increased incidence of anuary, brachyury and anal atresia within a litter, subcutaneous edema and increased rates of absorbed embryos at dosing levels toxic to parent animals in mouse three-generation tests and rat and mouse teratogenicity tests, described in CERI-NITE Hazard Assessment No.16 (2004) and IRIS (2001). Although an increase in conception rates in the F1 generation (CERI-NITE Hazard Assessment No.16, 2004), an increase in epididymidis weight and degeneration of duct epithelium of the cauda epididymidis (IRIS, 2001) were observed at dosing levels not toxic to parent animals in the mouse teratogenicity tests, and incomplete ossification of the skull (CERI-NITE Hazard Assessment No.16, 2004) was observed at dosing levels not toxic to parent animals in rabbit teratogenicity tests, the dosing level affecting the epididymis was not specified, and the rest of the changes seemed insignificant. Thus, placement of the substance in Category 2 seems appropriate.
8 Specific target organ toxicity - Single exposure Category 1 (liver, kidney), Category 3 (narcotic effects) Danger
Warning 		H370: Causes damage to organs (liver, kidney)
H336: May cause drowsiness or dizziness (narcotic effects) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on the human evidence including "necrosis of hepatic cells, liver damage, jaundice, hypertrophy of the liver, kidney damage, stertorous respiration, cyanosis and excessive sweating" (NITE Initial Risk Assessment No. 16, 2005) and the evidence from animal studies including "centrilobular fatty infiltration and necrosis of the liver, piloerection, sedation, musclar relaxation, ataxia, debility, partially watery eyes and necrosis of proximal convoluted tubules" (NITE Initial Risk Assessment No. 16, 2005). The effects on experimental animals were observed at dosing levels within the guidance value range for Category 1.
9 Specific target organ toxicity - Repeated exposure Category 1 (central nervous system, kidney, liver, respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (central nervous system, kidney, liver, respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "fatigue, thirst, gastrointestinal pain, frequent and painful urination, difficulty in concentration, depression, irritability, jaundice caused by liver damage after exposure to chloroform" (NITE Initial Risk Assessment No. 16, 2005) and the evidece from animal studies including "thickening of the nasal bone, atrophy and metaplasia of the olfactory epithelium, hypertrophy of the nuclei of proximal tubular epithelial cells, tubular dilation of renal tubules, necrosis of proximal renal tubules and focal degeneration of hepatic cells" (NITE Initial Risk Assessment No. 16, 2005). The effects on experimental animals were observed at dosing levels within the guidance value range for Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 96 hours LC50=1.24-2.03mg/L of the fish (Rainbow Trout) (CICAD58, 2004).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Although acute toxicity was Category 2 and the bio-accumulation potential was low (BCF=13(Existing Chemical Safety Inspections Data)), since there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information