GHS Classification Result

Chemical Name：Chloroethane
CAS：75-00-3

Result：
ID: 23
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Classified as "gas" according to GHS definition
2 Flammable gases （including chemically unstable gases） Category 1 Danger H220: Extremely flammable gas P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P377: Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P381: Eliminate all ignition sources if safe to do so.
P403: Store in a well-ventilated place. 		Based on the description in ICSC (2004): the lower explosion limit is 3.6vol%. Classified into Division 2.1 (UN#1037) (UN Recommendations on the Transport of Dangerous Goods)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not classified - - - - Classified into Division 2.1 (UN#1037) (UN Recommendations on the Transport of Dangerous Goods)
5 Gases under pressure Liquefied gas Warning H280: Contains gas under pressure; may explode if heated P410+P403: Protect from sunlight. Store in a well-ventilated place. The boiling point is 12.5degC (ICSC 2004), and the critical temperature is 187.2degC (Merck (13th, 2001)) - i.e., liquefied gas. Classified into Division 2.1 (UN#1037) (UN Recommendations on the Transport of Dangerous Goods)
6 Flammable liquids Not applicable - - - - Classified as "gas" according to GHS definition
7 Flammable solids Not applicable - - - - Classified as "gas" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Classified as "gas" according to GHS definition
9 Pyrophoric liquids Not applicable - - - - Classified as "gas" according to GHS definition
10 Pyrophoric solids Not applicable - - - - Classified as "gas" according to GHS definition
11 Self-heating substances and mixtures Not applicable - - - - Classified as "gas" according to GHS definition
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Classified as "gas" according to GHS definition
13 Oxidizing liquids Not applicable - - - - Classified as "gas" according to GHS definition
14 Oxidizing solids Not applicable - - - - Classified as "gas" according to GHS definition
15 Organic peroxides Not applicable - - - - Classified as "gas" according to GHS definition
16 Corrosive to metals Classification not possible - - - - Test methods applicable to gaseous substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - No data available
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not classified - - - - Based on the rat LC50 value of 40,700ppm representing the lower of the two testing data, 40,700ppm and 42,800ppm (4 hours), calculated from the testing data of rat LC50 (2-hour inhalation) of 57,576ppm (MOE Risk Assessment vol. 2 (2003)) and 60,632ppm (ACGIH (7th, 2001)).
1 Acute toxicity （Inhalation: Vapours） Not applicable - - - - Due to the fact that the substance is "gas" according to the GHS definition and inhalation of its vapour is not expected.
1 Acute toxicity （Inhalation: Dusts and mists） Not applicable - - - - Due to the fact that the substance is "gas" according to the GHS definition and inhalation of its dust/mist is not expected.
2 Skin corrosion/irritation Classification not possible - - - - Insufficient data available
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the description in the report on rabbit eye irritation tests (CERI Hazard Data 99-14 (2000)): Corneal opacity and corneal epithelial damage are observed. Classified into Category 2A-2B because the intensity of irritation is unknown, although the substance should be placed in Category 2A from the viewpoint of safety, if further subclassification is needed.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Not classified - - - - Based on the absence of data on multi-generation mutagenicity tests and germ cell mutagenicity tests in vivo, and negative data on somatic cell mutagenicity tests in vivo (micronucleus tests), described in CERI-NITE Hazard Assessment No.41 (2004), NTP DB (Access on January 2006) and IARC (1999).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Due to the fact that the substance is classified as Category A3 by ACGIH (2001).
7 Reproductive toxicity Classification not possible - - - - Insufficient data available (no data available on reproductive effects)
8 Specific target organ toxicity - Single exposure Category 2 (respiratory system, liver, kidney), Category 3 (narcotic effects) Warning H371: May cause damage to organs (respiratory system, liver, kidney)
H336: May cause drowsiness or dizziness (narcotic effects) 		P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on the human evidence including "narcotic effects" (NITE Initial Risk Assessment No.41 (2005)), and the evidence from animal studies including "histologic changes in the lungs, liver and kidneys" (CERI Hazard Data 99-14 (2000)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, nervous system), Category 2 (respiratory system) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (liver, nervous system)
H373: May cause damage to organs through prolonged or repeated exposure (respiratory system) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "hepatomegaly, temporary hepatic function disorder, epileptic seizure, ataxia, gait disorder, disorientation, temporary lapse of memory, hallucination" (NITE Initial Risk Assessment No.41 (2005)), and the evidence from animal studies including "hepatic function disorder, a decrease in blood pressure, a decrease in the capacity of phagocytes, hepatic fatty degeneration, hypertrophy of the alveolar septum" (CERI Hazard Data 99-14 (2000)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
10 Aspiration hazard Not applicable - - - - Due to the fact that the substance is a gas at ordinary temperatures.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 48 hours EC50=58mg/L of the crustacea (Daphnia magna) (CERI/NITE Hazard Assessment Report (2004) and others.).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Although acute toxicity was Category 3 and the bio-accumulation potential was low (log Kow=1.43(PHYSPROP Database, 2005)), since there was no rapidly degrading (the decomposition by BOD: 1%(Existing Chemical Safety Inspections Data)), it was classified into Category 3.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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