GHS Classification Result

Chemical Name:Lead chromate
CAS:7758-97-6

Result:
ID: 21
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no atom groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Non-flammable (ICSC,2004)
8 Self-reactive substances and mixtures Not applicable - - - - Containing no atom groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC,2004)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (ICSC,2004)
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (water solubility: 5.8microg/100mL(25degC), ICSC (2004))
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Classification not possible - - - - Classification not possible due to the absence of data, though being inorganic compounds containing oxygen.
15 Organic peroxides Not applicable - - - - Not organic compounds
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Classification not possible - - - - Insufficient data available [Note] The following description is found in ACGIH (7th, 2001): "The health hazard presented by PbCrO4, in comparison with that from other lead and chromium compounds, has long been a matter of dispute. Chromate salts are, in general, corrosive as a result of their oxidizing properties. Some authorities held that it presented little toxic hazard because of its extreme insolubility. Others considered it to be a hazard from both its lead and chromate content (see current TLV Documentations for Lead and Chromium compounds)."
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - Cannot be classified due to the lack of data, although the substance may cause irreversible skin irritation of an unknown degree, based on the following descriptions on human health effects of hexavalent chromium and chromium compounds: "Necrosis and sloughing of the skin occurred in individuals at the site of application of a salve containing potassium chromate" (ATSDR, 2000) and "ulceration is likely to occur among workers who have contact with high concentrations of chromic acid, sodium or potassium dichromate or chromate, or ammonium dichromate. It does not result from contact with trivalent chromium compounds" (EHC 61, 1988).
3 Serious eye damage/eye irritation Classification not possible - - - - Cannot be classified due to the lack of data, although the substance may cause irreversible or reversible effect of an unknown degree, based on the following description of human health effects of hexavalent chromium and chromium compounds provided by EU-RAR No.53 (2005): "Accidental splashing of highly water-soluble Cr(VI) compounds in solution into the eye has resulted in damage to the human eye. A number of case reports have detailed both inflammation of the cornea and conjunctivae and in more severe cases, corneal erosion and ulceration. The severity of response is increased by low pH or high temperature. Accidental eye contact with the corneal edema and opacity" and "severe and persistent eye and skin effects, including ulcers, have been observed in humans following single or repeated exposures."
4 Respiratory sensitization Classification not possible - - - - Cannot be classified due to the following reasons: the Task Force of the Japanese Society of Occupational Allergy includes chromium in its list, and the Japan Society for Occupational Health classifies chromium as "Category 2"; meanwhile, although these classifications refer to chromium or its compounds, they do not specify all of the substances relevant to sensitization, and it is unclear whether the present substance is identified as a sensitization. Moreover, CaPSAR (1994) contains a description of human health effects that chromium caused sensitization of an unknown degree, but it is unclear whether this also applies to the present substance.
4 Skin sensitization Classification not possible - - - - Cannot be classified due to the following reasons: the Task Force of the Japanese Society of Occupational Allergy includes chromium in its list, and the Japan Society for Occupational Health classifies chromium as "Category 2"; meanwhile, although these classifications refer to chromium or its compounds, they do not specify all of the substances relevant to sensitization, and it is unclear whether the present substance is identified as a sensitization. Moreover, CaPSAR (1994), EHC 61 (1988), ACGIH (7th, 2001), EU-RAR No.53 (2005), DFGOT vol.15 (2001), ECETOC TR45 (1994), PATTY (4th, 2000) and ATSDR (2000) contain descriptions on chromium giving positive results in patch tests, but it is unclear whether this also applies to the present substance.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the absence and presence of positive data on heritable mutagenicity tests and in vivo mutagenicity tests (micronucleus tests), respectively, described in RTECS (2005), although the type of cells used in the latter tests are not specified (i.e. germ or somatic cells). Moreover, a considerable number of mutagenicity and genotoxicity tests in vitro were conducted and positive results were obtained in almost all of them.
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Due to the fact that the substance is classified as Category K (as hexavalent chromium (VI) compounds) by NTP (2005), Group 1 (as chromium (VI)) by IARC (1990) and Category 1 (as chromium (VI) compounds) by the Japan Society for Occupational Health.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the evidence of reproductive toxicity of lead, inorganic lead compounds and lead chromate in ACGIH-TLV (2004) and the evidence of potential reproductive and developmental toxicity of lead chromate to humans in ICSC (2002), although no data is available for the present substance.
8 Specific target organ toxicity - Single exposure Category 1 (hematopoietic system, blood system, kidney, nervous system) Danger H370: Causes damage to organs (hematopoietic system, blood system, kidney, nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the human evidence including "anorexia, vomiting, discomfort, convulsion, irreversible brain damage"(HSDB (2002) and the evidence of "effects on hematopoietic function, hemoglobin synthesis inhibition, anemia caused by shortened survival of red blood cells, proximal renal tubular damage showing Fanconi's syndrome represented by proteinuria, hematuria, urinary cast, glycosuria and aminoaciduria, effects on the central and peripheral nervous systems" observed as acute toxicity of inorganic lead (CERI Hazard Data 2001-9 (2002).
9 Specific target organ toxicity - Repeated exposure Category 1 (hematopoietic system, blood system, kidney, nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (hematopoietic system, blood system, kidney, nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
No data available Based on the evidence of "effects on hematopoietic function, hemoglobin synthesis inhibition, anemia caused by shortened survival of red blood cells, proximal renal tubular damage showing Fanconi's syndrome represented by proteinuria, hematuria, urinary cast, glycosuria and aminoaciduria, effects on the central and peripheral nervous systems" (CERI Hazard Data 2001-9 (2002)) as chronic toxicity of inorganic lead.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

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Model SDS by MHLW

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