GHS Classification Result

Chemical Name：1,1'-Ethylene-2,2'-bipyridinium dibromide
CAS：85-00-7

Result：
ID: 13
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Classification not possible - - - - No data available
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Based on the description as Not conbustible (ICSC (2001)) and Not flammable (Weiss, 2nd (1985)), it was classified as out of Category.
8 Self-reactive substances and mixtures Classification not possible - - - - Classification not possible due to lack of data
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Not classified because of "Not conbustible" (ICSC, 2001) and "Not flammable" (Weiss, 2nd, 1985)
11 Self-heating substances and mixtures Not classified - - - - Not classified because it is not conbustible(ICSC, 2001) and not flammable(Weiss, 2nd, 1985)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Containing no oxygen , chlorine and fluorine.
15 Organic peroxides Not applicable - - - - There are no chemical groups associated with peroxide present in the molecule.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available. The active ingredient is corrosive to metals.(HSDB, 2005)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as Category 3 based on LD50= 214mg/kg of oral administration in rats (Agricultural-Chemicals abstracts (1993)).
1 Acute toxicity （Dermal） Not classified - - - - Since death was not observed in 2000mg/kg in rats dermal administration test (Agricultural-Chemicals abstracts (1993)), it was set as outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Insufficient data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		In primary skin irritation test using rats, erythema was seen after the first application, and the applied part of skin epithelium and sloughing were seen after the second application. It recovered ten days after the third application, and new tissue was found regenerating at the applied part of the skin. Since diquat was considered to cause a mild irritation to the rat skin (Agricultural-Chemicals abstracts (1985)), it was classified as Category 2.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Although the Draize score in the primary eye irritation examination with a rabbit was 8 for second day, since it was set to 2 seven days afterward and had recovered mostly after that (Agricultural-Chemicals abstracts (1985)), it was referred to as Category2A.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Classified as Category 1 because positive results (31% of positive rate) were obtained (agrochemical abstract (2004)) in the skin sensitization test using guinea pigs.
5 Germ cell mutagenicity Not classified - - - - Based on the negative results in the in vivo micronucleus test using mouse somatic cells (Agricultural-Chemicals abstracts (2004)) and in the in vivo chromosome aberration test using mouse somatic cells (Agricultural-Chemicals abstracts (1989)), we regarded the substance as outside the categories.
6 Carcinogenicity Not classified - - - - Since it was classified into A4 by ACGIH, it was set as the outside of Category. The carcinogenicity test results with rat and mouse (Agricultural-Chemicals abstracts (1985)) is also endorsing this classification.
7 Reproductive toxicity Not classified - - - - Since effects on reproductive function or fertility property are not observed in three generations of rat reproduction study(Agricultural-Chemicals abstracts (1977)) and bad effect to development of neonatal was not observed in a rat teratogenicity studies (Agricultural-Chemicals abstracts (1989)) or in a rabbit teratogenicity study (Agricultural-Chemicals abstracts (1985)), they were considered as on the outside of Categry.
8 Specific target organ toxicity - Single exposure Category 1 (systemic toxicity) Danger H370: Causes damage to organs (systemic toxicity) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		An acute neurotoxicity study in rats showed no neurotoxicity, but diarrhea, piloerection, urinary incontinence, upward curvature of the spine, tiptoe gait, opisthotonus and motor suppression were observed in females which had been given 150mg/kg of the substance (equivalent to the guidance value for Category 1) (Agricultural Chemical Abstracts, (2004)). So the substance was classified as Category 1 (systemic toxicity).
9 Specific target organ toxicity - Repeated exposure Category 2 (eye) Warning H373: May cause damage to organs through prolonged or repeated exposure (eye) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Since the cataract was observed in the oral repeated administration toxicology studies in rat for 90 days (correspond at 400 ppm (male : 32.4, female : 38.5mg/kg/day, correspond to a guidance value of Category 2 ) (Agricultural Chemicals abstracts (2004)), it was classified into Category 2 (eye).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		it was classified into Category 1 from the 96-hour ErC50=19microg diquat ion /L of algae (Green algae)(Agricultural Chemical Registration Data, 2003) .
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity was Category 1, not rapidly degrading (BOD: 0% (existing chemical safety inspections data)), though less bioaccumulative (BCF=1.4 (existing chemical safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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