GHS Classification Result

Chemical Name：Aniline
CAS：62-53-3

Result：
ID: 7
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		The flash point is 70degC (c.c.) (ICSC, 2004), which is classified into Category 4. Classified into Division 6.1 (UN#1547) (UN Recommendations on the Transport of Dangerous Goods).
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 615degC (ICSC, 2004)
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Not classified - - - - Classified into Division 6.1 (UN#1547) (UN Recommendations on the Transport of Dangerous Goods)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 444mg/kg calculated from the testing data of rat LD50 (dermal route) of 440mg/kg (MOE Risk Assessment Vol. 1, 2002), 440mg/kg (ACGIH (7th, 2001)), 780mg/kg, 930mg/kg (EU-RAR No.50 (2004)).
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LD50 (dermal route) of 442mg/kg (EU-RAR No.50 (2004)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the LC50 value (4 hours) of 300ppm, calculated from the testing data of rat LC50 (4 hour inhalation of vapor) of 1mg/L (4 hours) (EU-RAR No.50 (2004), was lower than 90% of the saturated vapor concentration (400ppm) under a saturated vapour pressure of 0.04kPa (20degC) (ICSC (2004)), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm.
1 Acute toxicity （Inhalation: Dusts and mists） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on the LC50 value (4 hours) of 2.3mg/L, calculated from the testing data of rat LC50 (inhalation of vapor) of 5.1mg/L (4 hours) (CaPSAR (1994)), 3.3mg/L (4 hours) (EU-RAR No.50 (2004)), 3.19mg/L(4 hours) (EU-RAR No.50 (2004)), 1.82mg/L (4 hours) (EU-RAR No.50 (2004)) was higher than of the saturated vapor concentration (400ppm) under a saturated vapour pressure of 0.04kPa (25degC) (ICSC (2004)), the substance was considered as "mist".
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on the description in the report on the rabbit skin irritation test (CERI-NITE Hazard Assessment No.63 (2004) and EU-RAR No.50 (2004)): "moderate irritant".
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the description in the report on the rabbit eye irritation test (CERI-NITE Hazard Assessment No.63 (2004) and EU-RAR No.50 (2004)): "severe irritant".
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the testing data of guinea pig skin sensitization tests (EU-RAR No.50 (2004)) and data on human health effects (CERI-NITE Hazard Assessment No.63 (2004), EU-RAR No.50 (2004)) - both positive.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the absence of data on multi-generation mutagenicity tests and germ cell mutagenicity tests in vivo, positive data on somatic cell mutagenicity tests in vivo (micronucleus tests), and the absence of data on germ cell genotoxicity tests in vivo, described in CERI-NITE Hazard Assessment No.63 (2004) and EU-RAR No. 50 (2004).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Due to the fact that the substance is classified as Category 3 by EU (2004), Category B2 by IRIS (2005) and Category A3 by ACGIH (2005).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the results of rat/mouse developmental toxicity studies: body weight reduction, an increase in the relative weight of the liver, effects on blood are observed in offspring at dose levels toxic to parent animals. (No data are available on reproductive toxicity.)
8 Specific target organ toxicity - Single exposure Category 1 (blood system, heart, liver, kidney, respiratory system, nervous system) Danger H370: Causes damage to organs (blood system, heart, liver, kidney, respiratory system, nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the human evidence including "dizziness, coma, contraction of the pupil, confusion, achromasia, cyanosis," and "formation of methemoglobin, myocardial/hepatic/renal degeneration, pulmonary/cerebral edema, bulbar hemorrhage" (CERI-NITE Hazard Assessment No.63 (2004)).
9 Specific target organ toxicity - Repeated exposure Category 1 (blood system, nervous system, respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (blood system, nervous system, respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "cyanosis, headache, dizziness, dysphagia, nausea, vomiting, chest/abdominal pain or convulsions, hyposthenia, palpitation, irregular respiration, contraction of the pupil (reactive to light), hypothermia, aniline odor in exhalation and perspiration, dark urine, pulmonary edema (in severe cases), acraturesis, encopresis" (CERI-NITE Hazard Assessment No.63 (2004)) and the evidence from animal studies including "enlargement/blackening of the spleen, extramedullary hematopoiesis, an increase in methemoglobin and Heinz bodies, reticulocytosis, enlargement of the spleen and liver, degradation of the spleen and kidneys, hemosiderin deposition in the adrenal and liver, an increase in mean cell volume, a decrease in red blood cell count, hemoglobin concentrations, hematocrit levels, mean corpuscular hemoglobin concentrations and erythroid bone marrow cells" (CERI-NITE Hazard Assessment No.63 (2004)). Severe effects on nervous systems and respiratory organs, due probably to methemoglobinemia, are observed. The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 48 hours LC50=80microg/L of the crustacea (Daphnia magna) (MOE Risk Assessment vol. 1, 2002).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since there was rapidly degrading (the decomposition by BOD: 85% (Existing Chemical Safety Inspections Data)) and the bio-accumulation was low (log Kow=0.9 (PHYSPROP Database, 2005)), it was claasified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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