GHS Classification Result

Chemical Name：Acetonitrile
CAS：75-05-8

Result：
ID: 6
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		The flash point is 12.8degC (c.c.) and the boiling point is 82degC (ICSC, 2002), which is classified into Category 2. Classified into Class 3 and Packing Group II (UN#1648) (UN Recommendations on the Transport of Dangerous Goods).
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures; the auto-ignition temperature is 524degC (ICSC, 2002)
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Not classified - - - - Classified into Class 3 (UN Recommendations on the Transport of Dangerous Goods, UN#1648)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Based on the LD50 value of 2,080 mg/kg calculated from the testing data of rat LD50 (oral route) of 3,800mg/kg, 1,320mg/kg, 2,460mg/kg, 2,230mg/kg, 1,730mg/kg, 6,740mg/kg, 3,200mg/kg, 160mg/kg, 3,070mg/kg, 3,470mg/kg and 4,050 mg/kg (EHC 154 (1993)).
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 390 mg/kg calculated from the testing data of rabbit LD50 (dermal route) of 3,940mg/kg, 980mg/kg, 390mg/kg (EHC 154 (1993)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Not classified - - - - Based on the LC50 value (4 hours) of 16,000ppm, calculated from the testing data of rat LC50 (4 hour inhalation of mist) of 26.8mg/L (4 hours) (EHC 154 (1993)), was lower than 90% of the saturated vapor concentration (117,000ppm) under a saturated vapour pressure of 88.8mmHg (25degC) (equivalent to 11,800Pa at 25degC) (HSDB (2005)), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified - - - - Based on the description in the report of rabbit skin irritation tests conducted in line with the EPA/OECD Guidelines (EU-RAR No.18 (2002)): Draize scores are all "0" for all subjects throughout the observation period; no skin irritation is observed.
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Because no information is available to separate 2A and 2B, although the substance should be placed in Category 2A from the viewpoint of safety. According to the rabbit eye irritation tests, the average scores of corneal opacity and conjunctival injection stand at 1.45 and 3, respectively (Category 2) (EU-RAR No.18 (2002)).
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - Insufficient data available. The literature on Priority 1 has no description of cases in humans, though the report of guinea pig skin sensitization test (GLP test conducted in line with the OECD Test Guidelines), which has been conducted only once, are reliably "negative."
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the absence of data on multi-generation mutagenicity tests and germ cell mutagenicity tests in vivo, positive data on somatic cell mutagenicity tests in vivo (micronucleus tests) and the absence of data on germ cell genotoxicity tests in vivo, described in EU-RAR No.18 (2002) and DFGOT vol.19 (2003).
6 Carcinogenicity Not classified - - - - Due to the fact that the substance is classified as Category A4 by ACGIH (2002) and Group D by EPA (1999).
7 Reproductive toxicity Classification not possible - - - - Insufficient data available (no data available on the reproductive function and fertility potential of parent animals)
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system, respiratory system) Danger H370: Causes damage to organs (central nervous system, respiratory system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the human evidence including "pectoralgia, tightness of the chest, nausea, vomiting, tachycardia, hypotension, tachypnea, headache, insomnia, clouding of consciousness, spasm" (CERI Hazard Data 96-17 (1997)), "flushing, tightness of the chest, pulmonary edema, convulsions, loss of consciousness" (MOE Risk Assessment Vol. 2 (2003)).
9 Specific target organ toxicity - Repeated exposure Category 2 (central nervous system, respiratory system, kidney, blood system, liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (central nervous system, respiratory system, kidney, blood system, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the evidence from animal studies including "hyperextensive reflex, excitement, asynergia, chronic pneumonia, pulmonary emphysema, atelectasis, pleural effusion, coagulation of alveolar histiocytes, cellular infiltration of alveolar septa, bronchitis, localized cloudy swelling of proximal convoluted renal tubules and convoluted renal tubules, localized extradural/subdural hemorrhage" (EU-RAR No.18 (2002)) and "a significant decrease in red blood cell count, hematocrit levels and hemoglobin concentrations, hepatocyte vacuolation/hypertrophy, bronchitis" (MOE Risk Assessment Vol. 2 (2003)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - It was classified into Not classified from 96 hours LC50>100mg/L of the fish (Oryzias Latipest) (MOE eco-toxicity tests of chemicals (1995) and others.).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since it was not water-insolubility (the water-solubility =1.00*106mg/L (PHYSPROP Database, 2005)), and acute toxicity was low, it was classified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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