GHS Classification Result

Chemical Name：Acrylonitrile
CAS：107-13-1

Result：
ID: 3
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no atom groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		The flashing point is -1degC (ICSC, 2004) (closed cup flash test) and the boiling point is 77degC; those containing stabilizers are classified into Class 3 and Category 6.1 (UN#1093) (UN Recommendations on the Transport of Dangerous Goods)
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Classification not possible - - - - Classification not possible due to lack of data, though containing unsaturated bonds. Those containing stabilizers are classified into Class 3 and Category 6.1 (UN#1093) (UN Recommendations on the Transport of Dangerous Goods)
9 Pyrophoric liquids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the flashing point is 481degC (ICSC,2004)
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen. fluorine and chlorine
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - No data available; those containing stabilizers are classified into Class 3 and Category 6.1 (UN#1093) (UN Recommendations on the Transport of Dangerous Goods)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 87mg/kg calculated from the testing data of rat LD50 (oral route) of 93mg/kg, 101mg/kg, 128mg/kg, 82mg/kg, 86mg/kg, 84mg/kg, 72mg/kg, 78mg/kg and 186mg/kg" (EHC 28, 1983).
1 Acute toxicity （Dermal） Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LD50 (dermal route) value of 148mg/kg representing the lower of the two testing data, 148mg/kg and 282 mg/kg (EHC 28, 1983).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LC50 value of 0.54 mg/L (243ppm), calculated from the testing data of rat LC50 (inhalation of vapour) of 0.47mg/L (4 hours), 1.03mg/L (4 hours) and 1.21mg/L (4 hours) (EU-PAR No.32, 2004), was lower than 90% of the saturated vapor concentration (110,000ppm) under a saturated vapour pressure of 11 kPa (20degC) (IPCS, 2001), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on the evidence of erythema and edema and an average Draize score of 3.6 obtained in rabbit skin primary irritation tests (EU-RAR No.32, 2004), although no data are available for applications of less than 4 hours.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the following description by DuPont (1975) on serious eye damage/eye irritation among several testing data in EU-RAR No.32, 2004: "In unwashed eyes, moderate corneal opacity, moderate iritis, severe conjunctival irritation and corneal opacity associated with vascularization observed even after 21 days from exposure. In washed eyes, mild temporary corneal opacity, moderate iris congestion, moderate conjunctival irritation, recovery observed within 3 days from exposure."
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on positive results in guinea pig maximization tests (CICAD, 39 2002).
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on negative data on heritable mutagenicity tests (dominant lethal tests) and germ cell genotoxicity tests in vivo (UDS tests on rat spermatocytes), the absence of data on germ cell mutagenicity tests in vivo and positive data on somatic cell mutagenicity tests in vivo (gene mutation tests on rat spleen T cells), described in CERI-NITE Hazard Assessment No.64 (2003), CICADS 39 (2002) and EU-RAR No.32 (2004).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Due to the fact that the substance is classified as Category R by NTP (2005) and Group 2B by IARC (1999).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence of organ and skeletal malformations in offspring at dosing levels toxic to dams in rat teratogenicity tests, described in CERI-NITE Hazard Assessment No. 64 (2003).
8 Specific target organ toxicity - Single exposure Category 1 (nervous system, liver), Category 3 (respiratory tract irritation, narcotic effects) Danger
Warning 		H370: Causes damage to organs (nervous system, liver)
H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects)
H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on the human evidence including "mild jaundice and spasm" (CERI-NITE Hazard Assessment No. 64, 2003), "effects on the central nervous system and the liver" (CICAD 39, 2002) and "eye, nasal and respiratory irritation, spasm, loss of consciousness and asphyxia" (NICNAS, 2000), with some of the effects on the nervous systems being temporal and reversible (CERI-NITE Hazard Assessment No. 64, 2003).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, respiratory system, blood system, testis, kidney, liver) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system, respiratory system, blood system, testis, kidney, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "central nervous system symptoms including anxiety, headache and nervous breakdown" (CERI Hazard Data 96-3, 1997), "pain in the eyes, nose, throat and respiratory tract" (CERI-NITE Hazard Assessment No. 64, 2003) and "decreases in hemoglobin levels and red and white blood cell counts, immunosuppression" (EU-RAR No.32, 2004) and the evidence from animal studies including "a decrease in sperm count, a decrease in physical capabilities, hyaline cast formation in renal collecting tubules, subacute bronchial pneumonia, focal necrosis in the liver, focal gliosis in the brain and cellular infiltration around the blood vessels" (CERI-NITE Hazard Assessment No. 64, 2003). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 96 hours LC50=5.81mg/L of the crustacea (Mysid Shrimp)) (CERI/NITE Hazard Assessment Report, 2005).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since there was rapidly degrading (the decomposition by BOD: 96% (Existing Chemical Safety Inspections Data)) and the bio-accumulation was low (log Kow=0.25 (PHYSPROP Database, 2005)), it was claasified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information