GHS Classification Result

Chemical Name：Acrylamide
CAS：79-06-1

Result：
ID: 1
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no atom groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Classified into Division 6.1 (UN Recommendations on the Transport of Dangerous Goods, UN#2074)
8 Self-reactive substances and mixtures Not classified - - - - Based on the classification by UN Recommendations on the Transport of Dangerous Goods (Category 6.1, UN#2074)
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the flashing point is 424degC (ICSC,2004)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available - melting point: 84.5degC (ICSC, 2004), test temperature: 140degC
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 129mg/kg calculated from the testing data of rat LD50 (oral route) of 124mg/kg (EHC 49, 1985), 175mg/kg (EU-RAR No.24, 2002) and 203mg/kg (EU-RAR No.24, 2002).
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LD50 (dermal route) value of 400mg/kg representing the lower of the two testing data, 400mg/kg (EHC 49,1985) and 1,148mg/kg (EU-RAR No.24, 2002).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on the testing data of rabbit skin irritation tests (EU-RAR No.24, 2002) and the data on human health effects (EU-RAR No.24, 2002 and ACGIH 7th, 2005), suggesting that the substance "causes mild skin irritation".
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the description found in the report on rabbit eye irritation tests (EU-RAR No.24, 2002): "eye irritation was observed but disappeared during the observation period of 21 days".
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on positive results in guinea pig skin sensitization tests (EU-RAR No.24, 2002), suggesting that the substance "causes skin sensitization".
5 Germ cell mutagenicity Category 1B Danger H340: May cause genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on positive data on in vivo germ cell heritable mutagenicity tests (dominant lethal tests, specific locus tests), described in CERI-NITE Hazard Assessment No.35 (2004).
6 Carcinogenicity Category 1B Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the fact that the substance is classified as Group 2A by IARC (1994) and Category R by U.S. NTP (2005).
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence of decreased number of foetuses per brood, decline in the ability of males to impregnate females, increased incidence of preimplantation embryo death, etc. at dosing levels causing no general toxicity (CERI-NITE Hazard Assessment No. 35, 2004).
8 Specific target organ toxicity - Single exposure Category 1 (nervous system, testis) Danger H370: Causes damage to organs (nervous system, testis) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the human evidence including "hallucination, hypotension, epileptic convulsion and peripheral neuropathy, of which peripheral neuropathy being observed also after two months" (EU-RAR No.24 (2002) and the evidence from animal studies including "tremor, hyperreflexia, repetitive tonic-clonic convulsion, asynergia of the hind limb, asynergia of posture and movement, dysfunction of hind limb muscles, vacuolation of sperm cell nuclei" (EU-RAR No.24 (2002), suggesting poor recoverability from neuropathy. The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, testis) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system, testis) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "disturbance in gait, dysmnesia, hallucination, speech disorder, numbness of the limbs, abnormal sweating of hands and feet, taste disorder" (CERI-NITE Hazard Assessment No. 35, 2004) and "muscular weakness, asynergia of arms, tremor of hands, sensory disorder (vibration, pain, tactile and position sensations), decreased tendon and plantar reflexes, nystagmus, diffuse fibrosing of nerve fibers and swelling of axons associated with disappearance and demyelination (EU-RAR No.24, 2002)" and the evidence from animal studies including "loss of balance, decreased vision, weakness of hind limbs, tremor of forelimbs, axon degeneration in peripheral nerves and optic tract fibers, spinal cord damage, testicular atrophy, decreased numbers of sperm cells and spermatocytes, decreased sperm count" (CERI-NITE Hazard Assessment No. 35, 2004). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 72 hours EC50=16.9mg/L of (EU-RAR, 2002).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since there was rapidly degrading (the decomposition by BOD: 70% (Existing Chemical Safety Inspections Data)) and the bio-accumulation was low (log Kow=-0.67 (PHYSPROP Database, 2005)), it was claasified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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